Pro‐inflammatory monocytes are increased in Duchenne muscular dystrophy and suppressed with omega‐3 fatty acids: A double‐blind, randomized, placebo‐controlled pilot study

Autor: Carlos Wong-Baeza, Alan Cárdenas-Conejo, Marco Antonio Villaldama-Soriano, Maricela Rodríguez-Cruz, Sthephanie Y. Hernández-De la Cruz, Tomas Almeida-Becerril
Rok vydání: 2021
Předmět:
Zdroj: European Journal of Neurology. 29:855-864
ISSN: 1468-1331
1351-5101
DOI: 10.1111/ene.15184
Popis: BACKGROUND Omega-3 long chain polyunsaturated fatty acids (LCPUFA) reduce circulating cytokines produced by monocytes. Nevertheless, whether the omega-3 LCPUFA regulate the monocytes and their cytokines in Duchenne muscular dystrophy (DMD) is unknown. The aim of this study was to evaluate whether circulating pro-inflammatory monocytes are increased and whether omega-3 LCPUFA selectively suppress these monocytes and their cytokines in patients with DMD. METHODS This was a double-blind, randomized, placebo-controlled pilot study carried out in patients with DMD supplemented with omega-3 LCPUFA (n = 6) or sunflower oils (placebo, n = 6) for 6 months. Monocytes and their cytokines were measured at baseline and after 1, 2, 3, and 6 months of supplementation. RESULTS The anti-inflammatory monocytes (median, [95% CI]) are increased at month 3 (-0.46 [-13.5-9.5] vs. 8.4 [5.5-12.5], p = 0.05) in the omega-3 LCPUFA group compared with the placebo group. The pro-inflammatory monocytes (-5.7 [-63.8-114.1] vs. -51.9 [-91.2 to -25.4], p = 0.026 and -16.4 [-50.8-50.6] vs. -57.9 [-86.9 to -18.5], p = 0.045 at months 3 and 6, respectively) and their cytokine interleukin 6 (-11.9 [-93.5-148.9] vs. -64.7 [-77.8 to -42.6], p = 0.019 at month 6) decreased in the omega-3 LCPUFA group compared with the placebo group. Pro-inflammatory monocytes decreased and anti-inflammatory monocytes were augmented (p
Databáze: OpenAIRE
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