Circulating Immature and Mature Dendritic Cells in Relation to Lymphocyte Subsets in Patients with Gastrointestinal Tract Cancer
| Autor: | M Vaghi, F. Brivio, E Fumagalli, L. Vigore, L. Fumagalli, Ferrante R, Fabio Malugani, R Bucovec, Paolo Lissoni |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male 0301 basic medicine Interleukin 2 Cancer Research medicine.drug_class Lymphocyte Clinical Biochemistry Monoclonal antibody Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immune system Antigens CD Stomach Neoplasms T-Lymphocyte Subsets medicine Humans Gastrointestinal Neoplasms Gastrointestinal tract business.industry Dendritic Cells T-Lymphocytes Helper-Inducer Dendritic cell Middle Aged medicine.disease Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Female Interleukin-3 receptor Lymphocytopenia Colorectal Neoplasms business Biomarkers medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/172460080001500104 |
| Popis: | Cancer-related deficiency in circulating dendritic cells (DC), whose important anticancer role is well established, has been proven to be associated with lymphocytopenia. This study was performed to evaluate which lymphocyte subset is most markedly related to the failure of the DC system. The study included 30 patients with gastrointestinal tract cancer, 10 of whom had distant organ metastases. Immature and mature DCs were measured by FACS and monoclonal antibodies against CD123 and CD11c antigens, respectively. Low levels of immature and mature DCs were observed in 63% and 43% of patients, respectively. Patients with low levels of circulating mature DCs had significantly lower values of T lymphocytes, T helper lymphocytes and NK cells than those with normal mature DC levels. In contrast, no significant difference was seen between patients with normal or abnormally low values of immature DCs. Conversely, patients with a decreased number of T lymphocytes, T helper lymphocytes and NK cells showed significantly lower values of circulating mature DCs than those with lymphocyte subsets within the normal range, whereas no difference was seen in immature DC amounts. This study suggests that only mature DC deficiency may be associated with important lymphocyte subset alterations in cancer patients, whereas deficiency in immature DCs does not seem to be related to other immune cell disorders. |
| Databáze: | OpenAIRE |
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