Study of Antitumor Activity of Sodium Phenylbutyrate, Histon Deacetylase Inhibitor, on Ehrlich Carcinoma Model
| Autor: | Yu. I. Pustovalov, R. I. Kharisov, E. G. Kovan’ko, N. P. Fadeev |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
media_common.quotation_subject Longevity Administration Oral Antineoplastic Agents Pharmacology Injections Intramuscular Phenylbutyrate General Biochemistry Genetics and Molecular Biology Ehrlich ascites carcinoma Mice Animals Outbred Strains medicine Carcinoma Animals Carcinoma Ehrlich Tumor media_common Antitumor activity business.industry Sodium phenylbutyrate General Medicine medicine.disease Phenylbutyrates Survival Analysis Tumor Burden Histone Deacetylase Inhibitors Toxicity Tumor growth inhibition Female business Neoplasm Transplantation medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 159:652-654 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-015-3039-x |
| Popis: | Antitumor activity of sodium phenylbutyrate was studied on 120 outbred female mice with transplanted Ehrlich ascites carcinoma. The animals received the drug in doses of 400, 800, and 1200 mg/kg with drinking water daily for 21 days. The antitumor effect was evaluated by tumor growth inhibition and lifespan prolongation. Phenylbutyrate in the dose of 800 mg/kg was most effective. The drug inhibited the tumor growth by 71%, prolonged the lifespan of animals by 28, and was low-toxic. |
| Databáze: | OpenAIRE |
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