Biomimetic Aerobic Oxidation of Amino Alcohols to Lactams
| Autor: | Jan-E. Bäckvall, Yoshinori Endo, Beneesh P. Babu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Lactams
Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry chemistry.chemical_element Ruthenium catalyst General Chemistry 010402 general chemistry Amino Alcohols 01 natural sciences Aerobiosis Catalysis 0104 chemical sciences Ruthenium Biomimetics Biomimetic synthesis Organometallic Compounds Organic chemistry Oxidation-Reduction |
| Zdroj: | Chemistry - A European Journal. 18:11524-11527 |
| ISSN: | 0947-6539 |
| Popis: | The right path: N-protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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