Candidate Genes for Suicide Risk in Head and Neck Squamous Cell Carcinoma Patients
Autor: | Elizabeth Joshua, Rooban Thavarajah, Umadevi K Rao, Anusa Arunachalam Mohandoss, Kannan Ranganathan |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Oncology
medicine.medical_specialty Candidate gene Population Orthodontics medicine.disease_cause Metastasis Transcriptome Internal medicine medicine education Mechanistic target of rapamycin suicide Cancer staging education.field_of_study biology business.industry mrna medicine.disease Head and neck squamous-cell carcinoma oral squamous cell carcinoma lcsh:RK1-715 Candidate genes for suicide lcsh:Dentistry biology.protein Oral Surgery Carcinogenesis business transcriptome |
Zdroj: | Journal of Orofacial Sciences, Vol 11, Iss 1, Pp 37-48 (2019) |
ISSN: | 0975-8844 |
Popis: | Intoduction: Suicide is relatively more common among cancer patients as compared to general population. There are several identified candidate genes for suicide (CGS). There is a dearth of research examining the association of differential expression (DE) of CGS among the treatment-naive head and neck squamous cell carcinoma (HNSCC) patients. The present study was undertaken to identify the DE of messenger Ribo Nucleic Acid (mRNA) of CGS in HNSCC tumor and correlate with clinical and other known genetic factors that promote oncogenesis as well as suicide. Material and Methods: Using previously described method, CGS lists were identified. The DE of the mRNA of the CGS were obtained from The Cancer Genome Atlas–HNSCC patients along with clinical details. The DE of mRNA pertaining to known factors such as inflammation, serotonergic, and dopaminergic functions as well as clinical parameters were studied for association with the risk of DE of CGS. Appropriate statistics were performed and P ≤ 0.05 was taken as significant. Results: A total of 520 HNSCC patients formed the study group. There were 46 (8.85%) patients who had DE of CGS. Expression of genes associated with inflammatory signaling pathway, ribosomal protein pathway, mechanistic Target of Rapamycin (mTOR), and metastasis, and invasion set of genes as well as the noradrenergic group of genes were associated significantly with DE of CGS. The association of DE of CGS and the major HNSCC clinical predictors of smoking, human papilloma virus status, clinical and cancer staging, histology grading, as well as patient status were not statistically significant. With a male predilection, gender exhibited statistically significant difference (P = 0.012). Discussion: In cancer patients, transcriptomes have been postulated to mediate suicide by targeted action on human brain. DE of putative genes associated with suicide have been demonstrated in HNSCC tumor. These DEs could predispose the patients to suicidal ideation/behavior in confluence with immediate psychosocial constructs. Addressing depression and suicidal thoughts in cancer patients would help to mitigate the risk of suicide. |
Databáze: | OpenAIRE |
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