Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors
| Autor: | Aaron J. Tyznik, Steven G. Self, Alexander Y. Rudensky, Denny Liggitt, Yuqiong Liang, Chyi-Song Hsieh |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
Transgene Immunology Receptors Antigen T-Cell Antigen-Presenting Cells chemical and pharmacologic phenomena Autoimmunity medicine.disease_cause Autoantigens Mice Antigen medicine Cytotoxic T cell Animals Immunology and Allergy IL-2 receptor Genetics MHC class II biology T-cell receptor hemic and immune systems Receptors Interleukin-2 Cell biology Self Tolerance Infectious Diseases biology.protein Peptides CD8 Spleen |
| Zdroj: | Immunity. 21(2):267-277 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2004.07.009 |
| Popis: | Naturally arising CD25+ CD4+ regulatory T cells (TR) play an important role in the prevention of autoimmunity. TCR specificity is thought to play a critical role in TR development and function, but the repertoire and specificity of TR TCRs remain largely unknown. We find by sequencing of TRAV14 (Valpha2) TCRalpha chains associated with a transgenic TCRbeta chain that the TRand CD25- CD4+ TCR repertoires are similarly diverse, yet only partially overlapping. Retroviral expression of TCRalpha genes in TCR transgenic RAG-deficient T cells revealed that a high frequency of TCRs derived from CD25+ but not CD25- CD4+ T cells confers the ability to rapidly expand upon transfer into a lymphopenic host. Thus, these data show that a large proportion of naturally arising TR have substantially more efficient interactions with MHC class II bound peptides from the peripheral self than CD25- T cells. |
| Databáze: | OpenAIRE |
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