Dependence of oxygen consumption on oxygen delivery in patients with chronic congestive heart failure
| Autor: | D. Amin, Zab Mohsenifar, Spencer K. Koerner, Prediman K. Shah, Alan C. Jasper |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Cardiac output ARDS Hemodynamics chemistry.chemical_element Critical Care and Intensive Care Medicine Mixed Venous Oxygen Tension Oxygen Nitroglycerin Oxygen Consumption Internal medicine medicine Humans Lactic Acid Heart Failure Respiratory distress business.industry Pulmonary Gas Exchange Oxygen transport medicine.disease Surgery chemistry Heart failure Cardiology Lactates Blood Gas Analysis Cardiology and Cardiovascular Medicine business human activities circulatory and respiratory physiology |
| Zdroj: | Chest. 92(3) |
| ISSN: | 0012-3692 |
| Popis: | We previously have shown that in patients with adult respiratory distress syndrome (ARDS) oxygen consumption (VO2) is linearly related to oxygen delivery (DO2) below a threshold DO2 of 21 ml/min/kg. To evaluate this relationship in chronic congestive heart failure (CHF), we studied eight patients with chronic CHF at baseline and during treatment with nitroglycerin. The resting DO2 and VO2 were 10.7 +/- 2.3 ml/min/kg and 3.8 +/- 0.87 ml/min/kg, respectively. In our eight patients, we found a significant relationship between changes in VO2 and in DO2 (delta VO2 = 0.16 + 0.34 X delta DO2, r = 0.84, n = 29). There was no significant relationship between DO2 and mixed venous oxygen tension (PvO2, r = 0.16), nor was there a significant relationship between cardiac output (Qt) and PvO2 (r = 0.21). We conclude that in patients with chronic CHF, changes in VO2 appear to be dependent on changes in DO2. This may represent an adaptive tissue response to chronically reduced systemic oxygen transport. |
| Databáze: | OpenAIRE |
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