Diamond Magnetic Microscopy of Malarial Hemozoin Nanocrystals
| Autor: | Pauli Kehayias, Victor M. Acosta, Nazanin Mosavian, Jong Seto, Ilja Fescenko, Abdelghani Laraoui, Janis Smits, Andrey Jarmola, Lykourgos Bougas |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
FOS: Physical sciences General Physics and Astronomy Nanoparticle Bioengineering 02 engineering and technology 01 natural sciences Article Crystal Paramagnetism Rare Diseases Engineering Mesoscale and Nanoscale Physics (cond-mat.mes-hall) parasitic diseases 0103 physical sciences Microscopy Nanotechnology Physics - Biological Physics 010306 general physics Saturation (magnetic) Condensed Matter - Mesoscale and Nanoscale Physics Hemozoin 021001 nanoscience & nanotechnology Magnetic susceptibility 3. Good health Malaria Vector-Borne Diseases Infectious Diseases Good Health and Well Being Biological Physics (physics.bio-ph) Chemical physics Physical Sciences 0210 nano-technology Superparamagnetism |
| Zdroj: | Physical review applied, vol 11, iss 3 Physical review applied |
| Popis: | Magnetic microscopy of malarial hemozoin nanocrystals was performed using optically detected magnetic resonance imaging of near-surface diamond nitrogen-vacancy centers. Hemozoin crystals were extracted from $Plasmodium$-$falciparum$-infected human blood cells and studied alongside synthetic hemozoin crystals. The stray magnetic fields produced by individual crystals were imaged at room temperature as a function of applied field up to 350 mT. More than 100 nanocrystals were analyzed, revealing the distribution of their magnetic properties. Most crystals ($96\%$) exhibit a linear dependence of stray field magnitude on applied field, confirming hemozoin's paramagnetic nature. A volume magnetic susceptibility $\chi=3.4\times10^{-4}$ is inferred using a magnetostatic model informed by correlated scanning electron microscopy measurements of crystal dimensions. A small fraction of nanoparticles (4/82 for $Plasmodium$-produced and 1/41 for synthetic) exhibit a saturation behavior consistent with superparamagnetism. Translation of this platform to the study of living malaria-infected cells may shed new light on hemozoin formation dynamics and their interaction with antimalarial drugs. Comment: Main text: 8 pages and 5 figures, Supplemental Information: 9 pages and 8 figures |
| Databáze: | OpenAIRE |
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