Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review

Autor: Alberto Migliore, Umberto Tarantino, Nicola Napoli, Nazzarena Malavolta, Silvia Migliaccio, Francesca Gimigliano, Andrea Giusti, Prisco Piscitelli, Giovanni Iolascon, Antimo Moretti, Massimiliano Bianco, Giuseppina Resmini, A. de Sire, Raffaele Gimigliano
Přispěvatelé: Iolascon, Giovanni, Gimigliano, Raffaele, Bianco, M., de Sire, A., Moretti, A., Giusti, A., Malavolta, N., Migliaccio, S., Migliore, A., Napoli, N., Piscitelli, P., Resmini, G., Tarantino, U., Gimigliano, Francesca
Rok vydání: 2017
Předmět:
0301 basic medicine
Gerontology
medicine.medical_treatment
Medicine (miscellaneous)
law.invention
chemistry.chemical_compound
Dietary supplement
Fluorides
0302 clinical medicine
Cognition
Randomized controlled trial
law
Dietary supplements
aging
cognitive function
musculoskeletal
nutraceuticals
Settore MED/33 - Malattie Apparato Locomotore
Medicine
Magnesium
Micronutrients
Musculoskeletal Diseases
Amino Acids
Vitamin D
Nutrition and Dietetics
Vitamin K2
Micronutrient
Zinc
Italy
Vitamin B Complex
nutraceutical
Vitamin
medicine.medical_specialty
030209 endocrinology & metabolism
Bone and Bones
03 medical and health sciences
Nutraceutical
Fatty Acids
Omega-3
Vitamin D and neurology
Humans
Vitamin B12
Muscle
Skeletal
Aged
030109 nutrition & dietetics
business.industry
Vitamin E
Calcium
Dietary
chemistry
Dietary Supplements
Physical therapy
Potassium
Geriatrics and Gerontology
business
Cognition Disorders
Zdroj: The journal of nutrition, healthaging. 21(5)
ISSN: 1760-4788
Popis: Objective: The aim of our scoping review was to summarize the state of the art regarding micronutrients in order to identify which of them might effectively improve health status in the areas typically impaired in older people: bone, skeletal muscle, and cognitive function. Design: Scoping review. Methods: The Italian Study Group on Healthy Aging by Nutraceuticals and Dietary Supplements (HANDS) performed this scoping review, based on the following steps: doing a list of micronutrients related with musculoskeletal or cognitive functions, included in dietary supplements and nutraceuticals commercialized in Italy; planning a research on PubMed, according to an evidence-based approach, in order to the most relevant positive study for each micronutrient into each of the three areas involved (bone, skeletal muscle and cognitive function); identifying the micronutrients effective in maintaining or achieving an adequate health status in older people, specifying the effective and safe daily doses, according to the selected studies. Results: In literature we found 12 relevant positive studies (1 international society guidelines/recommendations, 1 systematic review, 7 randomized controlled trials, and 3 prospective cohort studies). We showed that only 16 micronutrients resulted to have appropriate scientific evidences in terms of improving musculoskeletal health and/or cognitive function in older people: beta-alanine, calcium, creatine, fluorides, leucine, magnesium, omega-3 fatty acids, potassium, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K2, and zinc. Conclusion: This scoping review showed that selected micronutrients in adequate doses might have an ancillary role in musculoskeletal health and cognitive functions in older people. Objective: The aim of our scoping review was to summarize the state of the art regarding micronutrients in order to identify which of them might effectively improve health status in the areas typically impaired in older people: bone, skeletal muscle, and cognitive function. Design: Scoping review. Methods: The Italian Study Group on Healthy Aging by Nutraceuticals and Dietary Supplements (HANDS) performed this scoping review, based on the following steps: doing a list of micronutrients related with musculoskeletal or cognitive functions, included in dietary supplements and nutraceuticals commercialized in Italy; planning a research on PubMed, according to an evidence-based approach, in order to the most relevant positive study for each micronutrient into each of the three areas involved (bone, skeletal muscle and cognitive function); identifying the micronutrients effective in maintaining or achieving an adequate health status in older people, specifying the effective and safe daily doses, according to the selected studies. Results: In literature we found 12 relevant positive studies (1 international society guidelines/recommendations, 1 systematic review, 7 randomized controlled trials, and 3 prospective cohort studies). We showed that only 16 micronutrients resulted to have appropriate scientific evidences in terms of improving musculoskeletal health and/or cognitive function in older people: beta-alanine, calcium, creatine, fluorides, leucine, magnesium, omega-3 fatty acids, potassium, vitamin B6, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K2, and zinc. Conclusion: This scoping review showed that selected micronutrients in adequate doses might have an ancillary role in musculoskeletal health and cognitive functions in older people.
Databáze: OpenAIRE
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