Pre-existing chronic kidney disease and acute kidney injury among critically ill patients
| Autor: | Khalid Nabeel Alshlool, Maysoon S. Abdalrahim, Amani A. Khalil, Debra K. Moser, Manal Alramly, Mona A. Abed |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult medicine.medical_specialty Critical Illness Renal function Nursing 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine urologic and male genital diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine medicine Humans Rifle Hospital Mortality Renal Insufficiency Chronic Retrospective Studies Creatinine business.industry Mortality rate Medical record Acute kidney injury Retrospective cohort study Acute Kidney Injury medicine.disease female genital diseases and pregnancy complications Intensive Care Units 030228 respiratory system chemistry 1102 Cardiorespiratory Medicine and Haematology 1110 Nursing Cardiology and Cardiovascular Medicine business Kidney disease |
| Popis: | BACKGROUND:The impact of pre-existing chronic kidney disease (CKD) and acute kidney injury (AKI) on health outcomes in critically ill patients is unclear. Yet, CKD complicated by AKI in critically ill patients is common. OBJECTIVES:To compare risk of death within one-month of admission in critically ill patients with and without pre-existing CKD who developed AKI. METHODS:A multicenter retrospective comparative study using medical records review was conducted. Study participants consisted of 826 adult patients who received mechanical ventilation for at least 6 h in the critical care units from January 2012 to December 2017. Assessment of kidney function was established by serum creatinine. Severity and staging of AKI were defined using RIFLE criteria: Risk, Injury, Failure, Loss and End stage of renal disease. Chronic kidney disease was defined as eGFR > 60 ml/mg/1.73 m2 on admission. RESULTS:Pre-existing CKD was present in 55% of patients and 7% had AKI within 7 days of admission. The overall mortality rate among these patients was 87.3%. The mortality rate was highest in patients with CKD (70.1%) followed by that of patients without pre-existing CKD but with AKI (20.7%) and that of patients with pre-existing CKD (7.1%) and AKI. Risks associated with mortality were APACHE II score (1.03; 95% CI 1.02-1.05;(P |
| Databáze: | OpenAIRE |
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