KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel
| Autor: | Randy S. Wymore, Wenmei Shi, David McKinnon, Barry S. Brown, Hong-Sheng Wang, Zongming Pan, Jane E. Dixon, Ira S. Cohen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Indoles Patch-Clamp Techniques Potassium Channels Sympathetic Nervous System Pyridines Xenopus Protein subunit Gene Expression KCNQ3 Potassium Channel KCNQ2 Potassium Channel M current Animals Humans Patch clamp Anthracenes Neurons Ganglia Sympathetic Voltage-gated ion channel Chemistry Brain Tetraethylammonium Anatomy Potassium channel Rats Kinetics Electrophysiology nervous system Potassium Channels Voltage-Gated Oocytes Potassium Biophysics KCNQ4 |
| Zdroj: | Science. 282:1890-1893 |
| DOI: | 10.1126/science.282.5395.1890 |
| Popis: | The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current. |
| Databáze: | OpenAIRE |
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