Ambiguous Genitalia, Two Decades of Experience: Clinical Management and Sex Assignment
| Autor: | Nasir A.M. Al-Jurayyan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Virilization Sex assignment Saudi Arabia genitalia Grandparent General Medicine University hospital medicine.disease ambiguous Ambiguous genitalia children sex-assignment Medicine Clinical significance Congenital adrenal hyperplasia medicine.symptom business management Male gender |
| Zdroj: | Journal of Taibah University Medical Sciences. 5(1):13-20 |
| ISSN: | 1658-3612 |
| DOI: | 10.1016/s1658-3612(10)70119-0 |
| Popis: | Objective Ambiguous genitalia constitute a major social and medical emergency. This study was conducted to assess the relevant clinical significance of this important clinical entity. Methods During the period 1989-2008, eighty-one patients with ambiguous genitalia were evaluated in a Pediatric Endocrine Clinic at King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. Results Of these 53 (65.4%) were genetically females (46XX), and 28 (34.6%) were having a male genetic sex (46XY). The majority of them were proven to have congenital adrenal hyperplasia. Twenty-five (47.2%) of the genetic females were wrongly assigned a male sex due to severe virilization while only two (7.1%) of the genetic males were wrongly assigned as females. Although early neonatal diagnosis facilitates appropriate management, sociocultural factors such as a bias concerning the male gender in the community and strong influence of the grandparents constitute major management obstacle. All genetic males who were wrongly assigned as females accepted re-assignment, and four (16%) of the 25 genetic females who were wrongly assigned as males refused re-assignment. Conclusion A team approach is mandatory for successful management. Guidelines for approaching the problems are also highlighted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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