Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Autor: E.M. González-Gil, C. Cadenas-Sanchez, J. Santabárbara, G. Bueno-Lozano, I. Iglesia, M. González-Gross, D. Molnar, F. Gottrand, S. De Henauw, A. Kafatos, K. Widhalm, Y. Manios, A. Siani, F. Amaro-Gahete, A.I. Rupérez, D. Cañada, L. Censi, M. Kersting, J. Dallongeville, A. Marcos, F.B. Ortega, L.A. Moreno, C. Gilbert, C. Libersa, S. Castelló, M. Sjöstrom, D. Molnár, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, I. Labayen, S. Bel Serrat, L.A. Gracia Marco, T. Mouratidou, A. Santaliestra-Pasías, P. De Miguel-Etayo, C. Julián Almárcegui, M. Miguel-Berges, I. Iguacel, J. Wärnberg, E. Nova, S. Gómez, L.E. Díaz, J. Romeo, A. Veses, B. Zapatera, T. Pozo, D. Martínez, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Répasi, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, Á. Gutiérrez, J.R. Ruiz, E.G. Artero, V. España, D. Jiménez-Pavón, P. Chillón, C. Sánchez-Muñoz, M. Cuenca, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Roccaldo, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, I. Huybrechts, K. Phillipp, S. Dietrich, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, M. Hagströmer, A.H. Wennlöf, L. Hallström, E. Patterson, L. Kwak, N. Rizzo, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Thomas, E. Allchurch, P. Burgess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, R. Pedrero-Chamizo, A. Meléndez, J. Valtueña, U. Albers, P.J. Benito, J.J. Gómez Lorente, A. Urzanqui, R.M. Torres, P. Navarro
Přispěvatelé: González-Gil, E. M., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Iglesia, I., González-Gross, M., Molnar, D., Gottrand, F., De Henauw, S., Kafatos, A., Widhalm, K., Manios, Y., Siani, A., Amaro-Gahete, F., Rupérez, A. I., Cañada, D., Censi, L., Kersting, M., Dallongeville, J., Marcos, A., Ortega, F. B., Moreno, L. A., Gilbert, C., Libersa, C., Castelló, S., Sjöstrom, M., Molnár, D., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. Ma, Bueno, M., Labayen, I., Bel Serrat, S., Gracia Marco, L. A., Mouratidou, T., Santaliestra-Pasías, A., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Wärnberg, J., Nova, E., Gómez, S., Díaz, L. E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Gutiérrez, Ã ., Ruiz, J. R., Artero, E. G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Phillipp, K., Dietrich, S., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A. H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P. J., Gómez Lorente, J. J., Urzanqui, A., Torres, R. M., Navarro, P., Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Stockholm County Council, Ministerio de Ciencia e Innovación (España)
Rok vydání: 2017
Předmět:
Male
Pediatric Obesity
Cross-sectional study
Endocrinology
Diabetes and Metabolism
Health Status
Physiology
Medicine (miscellaneous)
030204 cardiovascular system & hematology
Body Mass Index
0302 clinical medicine
Risk Factors
Nutrition and Dietetic
adolescents
Metabolic Syndrome
Nutrition and Dietetics
biology
Age Factors
Interleukin
Complement C4
Inflammatory biomarkers
Complement C3
Prognosis
Europe
C-Reactive Protein
Female
medicine.symptom
Inflammation Mediators
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Adolescent
Metabolic health
030209 endocrinology & metabolism
Inflammation
03 medical and health sciences
Sex Factors
Internal medicine
medicine
Humans
business.industry
C-reactive protein
Case-control study
medicine.disease
Endocrinology
Blood pressure
Cross-Sectional Studies
Case-Control Studies
biology.protein
Metabolic syndrome
business
Body mass index
Inflammatory biomarker
Biomarkers
Zdroj: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
NMCD. Nutrition Metabolism and Cardiovascular Diseases (Testo stamp.) 28 (2018): 77–83. doi:10.1016/j.numecd.2017.10.004
info:cnr-pdr/source/autori:González-Gil EM, Cadenas-Sanchez C, Santabárbara J, Bueno-Lozano G, Iglesia I, González-Gross M, Molnar D, Gottrand F, De Henauw S, Kafatos A, Widhalm K, Manios Y, Siani A, Amaro-Gahete F, Rupérez AI, Cañada D, Censi L, Kersting M, Dallongeville J, Marcos A, Ortega FB, Moreno LA; HELENA study group./titolo:Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study/doi:10.1016%2Fj.numecd.2017.10.004/rivista:NMCD. Nutrition Metabolism and Cardiovascular Diseases (Testo stamp.)/anno:2018/pagina_da:77/pagina_a:83/intervallo_pagine:77–83/volume:28
Digital.CSIC. Repositorio Institucional del CSIC
ISSN: 1590-3729
2005-0070
Popis: On behalf of the HELENA study group.
[Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.
The HELENA Study was supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and the Stockholm County Council. This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) and the gs4:European Regional Development Fund (FEDER). CCS is supported by the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). FBO is supported by a grant from the Spanish Ministry of Science and Innovation (RYC-2011-09011). AIR was funded by a Juan de la Cierva-Formación stipend from the Ministry of Economy and Competitiveness of the Spanish Government (FJCI-2014-19795).
Databáze: OpenAIRE
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