Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly (N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Autor: Luke M. Geever, Shane C. Halligan, Megan Fallon, Romina Pezzoli, Clement L. Higginbotham
Rok vydání: 2019
Předmět:
Polymers and Plastics
temperature and pH responsive
Bioengineering
02 engineering and technology
macromolecular substances
010402 general chemistry
complex mixtures
01 natural sciences
Lower critical solution temperature
Article
Biomaterials
lcsh:Chemistry
chemistry.chemical_compound
lcsh:General. Including alchemy
physically cross-linked hydrogel
medicine
lcsh:Inorganic chemistry
Poly(N-vinylcaprolactam)
Itaconic acid
lcsh:Science
Comonomer
Organic Chemistry
Temperature and pH responsive
technology
industry
and agriculture
Physically cross-linked hydrogel
itaconic acid
021001 nanoscience & nanotechnology
lcsh:QD146-197
0104 chemical sciences
Drug delivery systems
Solvent
Poly (N-vinylcaprolactam)
chemistry
Polymerization
lcsh:QD1-999
Drug delivery
Self-healing hydrogels
drug delivery
Materials Research Institute AIT
lcsh:Q
Swelling
medicine.symptom
0210 nano-technology
lcsh:QD1-65
Nuclear chemistry
Zdroj: Gels
Gels, Vol 5, Iss 3, p 41 (2019)
Volume 5
Issue 3
ISSN: 2310-2861
Popis: Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this study, however, temperature sensitive PNVCL was physically crosslinked with a pH-sensitive comonomer IA through ultraviolet (UV) free-radical polymerization, without the presence of a solvent, to produce hydrogels with dual sensitivity. The attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy indicated successful polymerisation of the hydrogels. The temperature and pH sensitivity of the hydrogels was investigated. The lower critical solution temperature (LCST) of the gels was determined using the UV spectrometry and it was found that the incorporation of IA decreased the LCST. Rheology was conducted to investigate the mechanical and viscoelastic properties of the hydrogels, with results indicating IA that enhances the mechanical properties of the gels. Swelling studies were carried out at ~20 °
C and 37 °
C in different buffer solutions simulating the gastrointestinal tract (pH 2.2 and pH 6.8). In acidic conditions, the gels showed gradual increase in swelling while remaining structurally intact. While in basic conditions, the gels had a burst in swelling and began to gradually degrade after 30 min. Results were similar for drug release studies. Acetaminophen was incorporated into the hydrogels. Drug dissolution studies were carried out at 37 °
C in pH 2.2 and pH 6.8. It was found that <
20% of acetaminophen was released from the gels in pH 2.2, whereas the maximum drug released at pH 6.8 was 74%. Cytotoxicity studies also demonstrated the hydrogels to be highly biocompatible. These results indicate that physically crosslinked P(NVCL-IA) gels possess dual pH and temperature sensitive properties, which may be beneficial for biomedical applications such as drug delivery.
Databáze: OpenAIRE
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