Junctophilins: Key Membrane Tethers in Muscles and Neurons
| Autor: | Yishi Jin, Christopher A. Piggott |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
RyR channels Mini Review muscle excitation 1.1 Normal biological development and functioning Clinical Sciences Neurosciences. Biological psychiatry. Neuropsychiatry Neurotransmission Conserved sequence 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Underpinning research calcium channels synaptic transmission Molecular Biology Ion channel Calcium signaling ER-PM tethers Voltage-dependent calcium channel Chemistry Tethering Endoplasmic reticulum jph-1 Neurosciences Afterhyperpolarization ER–PM tethers Cell biology 030104 developmental biology membrane contact site proteins Neurological Generic health relevance 030217 neurology & neurosurgery Neuroscience RC321-571 |
| Zdroj: | Frontiers in Molecular Neuroscience, Vol 14 (2021) Frontiers in Molecular Neuroscience |
| Popis: | Contacts between the endoplasmic reticulum (ER) and plasma membrane (PM) contain specialized tethering proteins that bind both ER and PM membranes. In excitable cells, ER–PM contacts play an important role in calcium signaling and transferring lipids. Junctophilins are a conserved family of ER–PM tethering proteins. They are predominantly expressed in muscles and neurons and known to simultaneously bind both ER- and PM-localized ion channels. Since their discovery two decades ago, functional studies using junctophilin-deficient animals have provided a deep understanding of their roles in muscles and neurons, including excitation-contraction coupling, store-operated calcium entry (SOCE), and afterhyperpolarization (AHP). In this review, we highlight key findings from mouse, fly, and worm that support evolutionary conservation of junctophilins. |
| Databáze: | OpenAIRE |
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