Evaluation of neuroprotective effects of wedelolactone and gallic acid on aluminium-induced neurodegeneration: Relevance to sporadic amyotrophic lateral sclerosis
Autor: | T. Prakash, Divakar Goli, S. Maya |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Excitotoxicity Glutamic Acid Pharmacology medicine.disease_cause Neuroprotection Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Coumarins Gallic Acid medicine Animals Neuronal transport chemistry.chemical_classification Caspase 3 Interleukin-6 Tumor Necrosis Factor-alpha Chemistry Brain-Derived Neurotrophic Factor Glutathione peroxidase Amyotrophic Lateral Sclerosis Body Weight Neurodegeneration Glutamate receptor Wedelolactone medicine.disease Rats Neuroprotective Agents 030104 developmental biology Gene Expression Regulation Rotarod Performance Test Female 030217 neurology & neurosurgery Oxidative stress Aluminum |
Zdroj: | European Journal of Pharmacology. 835:41-51 |
ISSN: | 0014-2999 |
Popis: | Al exposure causes an alteration in the several ions in the body and causes toxicity. Such as apoptosis, oxidative stress, disruption in neuronal transport, mitochondrial damage, excitotoxicity, generation of inflammatory mediators, and microglial activation. These multiple mechanisms lead to the several neurodegenerative diseases, including sporadic amyotrophic lateral sclerosis (sALS). The study aims to unravel the mechanisms behind the neuroprotective effects of wedelolactone (WL) and gallic acid (GA) against aluminium-induced neurodegeneration and thereby to unlock a platform to find a cure for sALS. We studied the neuroprotective effects of WL (100 & 200 mg/kg) and GA (100 & 200 mg/kg) using aluminium chloride (AlCl3)-induced neurodegeneration model. The study was conducted using male Wistar rats. We assessed the effects of WL and GA on motor learning ability, motor coordination, locomotor activity, cytokine production, BDNF, glutathione peroxidase (GPx), m-calpain, caspase-3 inhibition and L -glutamate level. The study suggests that the treatment with WL and GA could protect the motor neurons from the toxicity that caused by Al via improving the antioxidant status, BDNF, and by preventing glutamate excitotoxicity. Also, WL and GA are found to be effective in inhibiting caspase-3 activation and downregulating inflammatory cytokines. WL and GA also found effective in improving the motor learning abilities and motor coordination in rats. The protective effects of the WL and GA were further confirmed from histopathological results. WL and GA prevent the neurofibrillary tangle formation and neuronal damage. The study concluded that the WL and GA were dose-dependently effective in managing the AlCl3-induced neurodegeneration. |
Databáze: | OpenAIRE |
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