Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients

Autor: Marisol Orozco-Ibarra, Mónica Adriana Torres-Ramos, Nicte Alaide Ramos-García, Laura Chávez Macías, Erick Gómez Apo, Ana Luisa Sosa-Ortiz, Enrique Estudillo, Guillermo Elizondo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Aging
AHR
microangiopathy
Hippocampus
neuroinflammation
lcsh:Chemistry
Mice
Blood serum
Basic Helix-Loop-Helix Transcription Factors
Aging brain
lcsh:QH301-705.5
Spectroscopy
Aged
80 and over
biology
Neurodegeneration
General Medicine
Middle Aged
respiratory system
Immunohistochemistry
Computer Science Applications
ARNT
Female
medicine.symptom
Adult
medicine.medical_specialty
Aryl hydrocarbon receptor nuclear translocator
Adolescent
Enzyme-Linked Immunosorbent Assay
Inflammation
Article
Catalysis
Inorganic Chemistry
Extracellular Vesicles
Young Adult
Alzheimer Disease
Internal medicine
Glial Fibrillary Acidic Protein
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Neuroinflammation
Aged
business.industry
Organic Chemistry
astrocytes
medicine.disease
Aryl hydrocarbon receptor
respiratory tract diseases
Mice
Inbred C57BL
Endocrinology
gliosis
lcsh:Biology (General)
lcsh:QD1-999
Receptors
Aryl Hydrocarbon
Gliosis
biology.protein
business
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1983 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21061983
Popis: One of the characteristics of the cerebral aging process is the presence of chronic inflammation through glial cells, which is particularly significant in neurodegeneration. On the other hand, it has been demonstrated that the aryl hydrocarbon receptor (AHR) participates in the inflammatory response. Currently, evidence in animal models shows that the hallmarks of aging are associated with changes in the AHR levels. However, there is no information concerning the behavior and participation of AHR in the human aging brain or in Alzheimer&rsquo
s disease (AD). We evaluated the expression of AHR in human hippocampal post-mortem tissue and its association with reactive astrocytes by immunohistochemistry. Besides this, we analyzed through ELISA the AHR levels in blood serum from young and elder participants, and from AD patients. The levels of AHR and glial fibrillar acid protein were higher in elder than in young post-mortem brain samples. AHR was localized mainly in the cytosol of astrocytes and displayed a pattern that resembles extracellular vesicles
this latter feature was more conspicuous in AD subjects. We found higher serum levels of AHR in AD patients than in the other participants. These results suggest that AHR participates in the aging process, and probably in the development of neurodegenerative diseases like AD.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje