High Efficiency BMP-2 Coatings: Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects (Adv. Sci. 2/2019)

Autor:	James F. C. Windmill, Elena S. Addison, Matthew J. Dalby, Sandra A. Corr, Hannah Donnelly, Manuel Salmerón-Sánchez, Peter G. Childs, Cristina González-García, Zhe A. Cheng, Laura Ruiz-Cantu, William G. Marshall, David W. Shields, Andres Alba-Perez, Virginia Llopis-Hernandez, Andrew Reid, Vineetha Jayawarna, Marco Cantini
Rok vydání:	2019
Předmět:	Materials science General Chemical Engineering Regeneration (biology) Cellular differentiation Ultralow dose General Engineering General Physics and Astronomy Medicine (miscellaneous) Biochemistry Genetics and Molecular Biology (miscellaneous) Bone morphogenetic protein 2 growth factor delivery bone regeneration Inside Front Cover General Materials Science stem cell differentiation Bone regeneration Nanoscopic scale biomaterials Biomedical engineering
Zdroj:	Advanced Science
ISSN:	2198-3844
DOI:	10.1002/advs.201970009
Popis:	In article number 1800361, Matthew J. Dalby, Manuel Salmeron‐Sanchez, and co‐workers coat structural material, e.g., particles or scaffolds, with a bioactive synthetic material that organizes fibronectin to present BMP‐2 with high efficiency. This is used as a novel regenerative approach to heal critical‐sized bone defects. Simultaneous integrin and growth factor receptor synergistic signaling drives stem cell differentiation leading to bone regeneration in the first veterinary patient.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0103bdb04e629f69e32dbf86c51eb86b https://doi.org/10.1002/advs.201970009 Zobrazit plný text záznamu Plný text