Lactobacillus johnsonii CJLJ103 attenuates colitis and memory impairment in mice by inhibiting gut microbiota lipopolysaccharide production and NF-κB activation
| Autor: | Dong-Hyun Kim, Su-Min Lim, Myung Joo Han, Hyo-Min Jang, Jin-Ju Jeong |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lipopolysaccharide Medicine (miscellaneous) Biology Gut flora digestive system law.invention Microbiology 03 medical and health sciences Probiotic chemistry.chemical_compound law Neurotrophic factors medicine TX341-641 Colitis Lactobacillus johnsonii Gut microbitoa Nutrition and Dietetics Nutrition. Foods and food supply Memory impairment medicine.disease biology.organism_classification Ulcerative colitis digestive system diseases 030104 developmental biology chemistry NF-κB activation Tumor necrosis factor alpha Food Science |
| Zdroj: | Journal of Functional Foods, Vol 34, Iss, Pp 359-368 (2017) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2017.05.016 |
| Popis: | Exposure to excessive lipopolysaccharide (LPS) by the gut microbiota disturbance causes ulcerative colitis and memory impairment. Therefore, we isolated anti-inflammatory Lactobacillus johnsonii CJLJ103 (LJ) from human fecal microbiota as an inhibitor for Escherichia coli growth and LPS production and investigated anti-colitic and memory impairment-ameliorating effects in mice. Oral administration of LJ inhibited 2,3,6-trinitrobenzenesulfonic acid (TNBS)-induced colon shortening, colonic myeloperoxidase activity, and NF-κB activation in mice. Furthermore, LJ inhibited TNBS-induced TNF and IL-1β expression in the colon but increased TNBS-suppressed expression of IL-10 and tight-junction proteins. Treatment with LJ inhibited fecal LPS levels and proteobacteria/bacteroidetes ratio in mice with TNBS-induced colitis. Furthermore, LJ ameliorated LPS-induced memory impairment in mice. LJ also suppressed LPS-induced NF-κB activation in the hippocampus and increased LPS-suppressed brain-derived neurotrophic factor expression. These findings suggest that LJ, a member of human gut microbiota, may ameliorate colitis and memory impairment, thereby acting as a useful probiotic. |
| Databáze: | OpenAIRE |
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