99m Tc-CD19 monoclonal antibody is not useful for imaging of B cell non-Hodgkin's lymphoma
| Autor: | P. A. Merle, S. F. Vervoordeldonk, A. E. G. K. Von Dem Borne, R. H. J. Van Oers, W. T. Goedemans, I. C. M. Slaper-Cortenbach, E. A. Van Royen, J. Heikens |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Lymphoma B-Cell Radioimmunoconjugate Antigens CD19 Immunology Pilot Projects Mice hemic and lymphatic diseases medicine Animals Humans Immunology and Allergy B-cell lymphoma Lymph node B cell Aged business.industry Antibodies Monoclonal Technetium medicine.disease Lymphoma Non-Hodgkin's lymphoma medicine.anatomical_structure Radioimmunodetection Oncology Female Lymph Nuclear medicine business Technetium-99m |
| Zdroj: | Cancer immunology, immunotherapy, 42(5), 291-296. Springer Science and Business Media Deutschland GmbH |
| ISSN: | 1432-0851 0340-7004 |
| Popis: | In this study we investigated the applicability of 99mTc-labeled CD19 monoclonal antibody (mAb) for tumor imaging in patients with B cell non-Hodgkin's lymphoma. A 1-mg sample of murine CD19 mAb was labeled with approximately 550 MBq [99mTc]pertechnetate. The labeled mAb was administered i.v. to seven patients, four without and three with pretreatment with 10 mg unlabeled CD19 mAb. The number of circulating B cells was decreased by 44 +/- 5% 1 h after injection of the radiolabeled mAb. Peripheral B cells were coated with CD19, resulting in partial modulation of CD19, most pronounced in the three pretreated patients. Whole-body images were obtained with a gamma camera and compared with results obtained by conventional imaging techniques. Initially, blood-pool activity dominated, whereas 24 h after injection the radioactivity was mainly located in the spleen, kidneys and liver. In two patients, a lesion in the spleen appeared as an unlabeled spot. In one patient, a lesion in the femur, which was detected by computed tomography (CT) and gallium-67 scans, was also seen on the CD19 scan from 1 h after administration of the radioimmunoconjugate onwards. Good imaging of bone marrow infiltration was observed in one of three patients. Lymph node involvement was not observed in any of the patients in whom affected lymph nodes were detected by CT or gallium-67 scan. In conclusion, in the present study radioimmunodetection with 99mTc-labeled CD19 mAb was found to be inferior to CT and gallium-67 scanning in the diagnosis of patients with B cell non-Hodgkin's lymphoma. |
| Databáze: | OpenAIRE |
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