Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation

Autor:	Signe Søvik, Andreas Barratt-Due, Trine Kåsine, Theresa Olasveengen, Marianne Wigernes Strand, Anders Aune Tveita, Jan Erik Berdal, Martin Andreas Lehre, Torleif Lorentsen, Lars Heggelund, Tore Stenstad, Jetmund Ringstad, Fredrik Müller, Pål Aukrust, Jan Cato Holter, Ingvild Nordøy
Rok vydání:	2022
Předmět:	Adult Aged 80 and over Male Microbiology (medical) SARS-CoV-2 COVID-19 Middle Aged Respiration Artificial Dexamethasone Autoimmune Diseases Infectious Diseases Adrenal Cortex Hormones Superinfection Humans Aged Retrospective Studies
Zdroj:	Journal of Infection
ISSN:	0163-4453
DOI:	10.1016/j.jinf.2022.05.015
Popis:	Objectives To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, and the impact of dexamethasone as standard therapy. Methods This multicentre, observational, retrospective study included patients ≥ 18 years admitted from March 1st 2020 to January 31st 2021 with COVID-19 infection who received mechanical ventilation. Patient characteristics, clinical characteristics, therapy and survival were examined. Results 155/156 patients (115 men, mean age 62 years, range 26-84 years) were included. 67 patients (43%) had 90 superinfections, pneumonia dominated (78%). Superinfections were associated with receiving dexamethasone (66% vs 32%, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010120841d158f16d843c211d72e3434 https://doi.org/10.1016/j.jinf.2022.05.015 Zobrazit plný text záznamu Full Text from ScienceDirect