The role of carbohydrate counting in glycemic control and oxidative stress in patients with type 1 diabetes mellitus (T1DM)
| Autor: | Eirini Kostopoulou, Fotini N. Lamari, Spyros Skiadopoulos, Andrea Paola Rojas Gil, Ioulia Livada, Bessie E. Spiliotis, Ioanna Partsalaki |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant endocrine system diseases Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism 030204 cardiovascular system & hematology medicine.disease_cause 03 medical and health sciences Carbohydrate counting chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine Malondialdehyde medicine Dietary Carbohydrates Humans Child Glycemic Glycated Hemoglobin Type 1 diabetes medicine.diagnostic_test business.industry General Medicine medicine.disease Oxidative Stress Endocrinology Diabetes Mellitus Type 1 chemistry Child Preschool Female Glycated hemoglobin Lipid profile business Oxidative stress |
| Zdroj: | Hormones (Athens, Greece). 19(3) |
| ISSN: | 2520-8721 |
| Popis: | Oxidative stress is closely related to type 1 diabetes mellitus (T1DM), playing a key role in the pathogenesis of the disease and progression of complications. It is characterized by loss of equilibrium between oxidative factors and antioxidant protective mechanisms. Several markers have been used to assess both components of oxidative status; two of which are malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP). We investigated glycated hemoglobin (HbA1c), lipid profile, MDA, and FRAP in 35 patients with T1DM, aged 2–23 years, at the end of two 4-month observational periods: period A: standard insulin dosing per meal, and period B: proper prandial insulin dosing based on the amount of carbohydrates contained in each meal. At the end of period B, (i) glucose control (HbA1c) was improved; (ii) oxidative stress, estimated by MDA, showed a tendency to decrease; and (iii) antioxidant capacity, estimated by FRAP, was significantly increased compared with that of period A. No significant differences were observed in the lipid profile of the patients between the two periods. Proper insulin dosing based on carbohydrate counting (CC) may have an impact on the antioxidant defensive mechanisms of patients with T1DM through the attainment of a better glycemic profile. There are also indications that it may reduce MDA, an important biomarker of oxidative stress and a significant mediator of complications in T1DM. Therefore, prompt dietetic intervention using CC as early as possible after the diagnosis of T1DM is important for achieving optimal glycemic control and improved oxidative status. |
| Databáze: | OpenAIRE |
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