Cellular signaling cross-talk between different cardiac cell populations: an insight into the role of exosomes in the heart diseases and therapy
| Autor: | Binh Yen Nguyen, Xin Wang, Tayyiba Azam |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell signaling Heart Diseases Physiology Cell Communication Review 030204 cardiovascular system & hematology Biology Exosomes 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Extracellular Animals Humans Receptor Transcription factor Myocardium Non-coding RNA Microvesicles Cell biology 030104 developmental biology chemistry Stem cell Cardiology and Cardiovascular Medicine DNA Signal Transduction Stem Cell Transplantation |
| Zdroj: | Am J Physiol Heart Circ Physiol |
| ISSN: | 1522-1539 |
| Popis: | Exosomes are a subgroup of extracellular bilayer membrane nanovesicles that are enriched in a variety of bioactive lipids, receptors, transcription factors, surface proteins, DNA, and noncoding RNAs. They have been well recognized to play essential roles in mediating intercellular signaling by delivering bioactive molecules from host cells to regulate the physiological processes of recipient cells. In the context of heart diseases, accumulating studies have indicated that exosome-carried cellular proteins and noncoding RNA derived from different types of cardiac cells, including cardiomyocytes, fibroblasts, endothelial cells, immune cells, adipocytes, and resident stem cells, have pivotal roles in cardiac remodeling under disease conditions such as cardiac hypertrophy, diabetic cardiomyopathy, and myocardial infarction. In addition, exosomal contents derived from stem cells have been shown to be beneficial for regenerative potential of the heart. In this review, we discuss current understanding of the role of exosomes in cardiac communication, with a focus on cardiovascular pathophysiology and perspectives for their potential uses as cardiac therapies. |
| Databáze: | OpenAIRE |
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