Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy
| Autor: | Marek Fischer, Huldrych F. Günthard, Annette Oxenius, Christine Schneider, Sarah J. Dawson, Angela R. McLean, Rainer Weber, Roland Hafner, Bernard Hirschel, Helen Joller, Rodney E. Phillips, David Price |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Immunology Human immunodeficiency virus (HIV) HIV Infections CD8-Positive T-Lymphocytes Biology CD8-Positive T-Lymphocytes/immunology medicine.disease_cause Microbiology Virology medicine Humans Cytotoxic T cell RNA Viral/blood Aged ddc:616 HIV Infections/drug therapy/ immunology/virology virus diseases T-Lymphocytes Cytotoxic/ immunology HIV-1/genetics/growth & development/ immunology Middle Aged Viral Load Antiretroviral therapy CTL Institutional repository Insect Science HIV-1 RNA Viral Pathogenesis and Immunity Clearance rate Viral load CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Virology, Vol. 76, No 20 (2002) pp. 10169-10176 |
| ISSN: | 0022-538X |
| Popis: | There is a continuing search for better ways to use existing drugs against human immunodeficiency virus (HIV). One idea is to use short therapy interruptions to “autovaccinate” HIV-infected patients. A group of 13 chronically HIV-infected patients enrolled in a trial of such so-called structured treatment interruptions (STIs) were intensively studied with respect to their viral load (VL) and HIV-specific CD8+T-cell (cytotoxic T-lymphocyte [CTL]) responses. We found that 10 of the 13 patients had plateau VLs after STIs that were lower than their pretreatment VLs. While viral rebound rates became lower over STIs, there were no changes in clearance rates. Although numbers of CTLs did increase over the same time that viral rebounds decreased, there was no correlation between CTL count and either viral rebound rates or clearance rates. Finally, we asked whether absolute numbers of or changes in numbers of CTLs predict plateau VLs after STIs. No measure of CTLs was able to predict plateau VLs. Thus, there was no signature in these data of an important contribution to virological control from HIV-specific CD8+T lymphocytes. |
| Databáze: | OpenAIRE |
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