Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly

Autor:	Keren L. Witkin, Orna Cohen-Fix, Micah T. Webster
Rok vydání:	2009
Předmět:	Cell Nucleus Shape Nuclear Envelope Mitosis Cell Biology Biology Endoplasmic Reticulum Cell biology medicine.anatomical_structure Cell Nucleus Size Commentary Nuclear Pore medicine Animals Humans Nuclear lamina Inner membrane Nuclear pore Nucleus Lamin
Zdroj:	Journal of Cell Science. 122:1477-1486
ISSN:	1477-9137 0021-9533
Popis:	The nucleus is one of the most prominent cellular organelles, yet surprisingly little is known about how it is formed, what determines its shape and what defines its size. As the nuclear envelope (NE) disassembles in each and every cell cycle in metazoans, the process of rebuilding the nucleus is crucial for proper development and cell proliferation. In this Commentary, we summarize what is known about the regulation of nuclear shape and size, and highlight recent findings that shed light on the process of building a nucleus, including new discoveries related to NE assembly and the relationship between the NE and the endoplasmic reticulum (ER). Throughout our discussion, we note interesting aspects of nuclear structure that have yet to be resolved. Finally, we present an idea – which we refer to as `the limited flat membrane hypothesis' – to explain the formation of a single nucleus that encompasses of all of the cell's chromosomes following mitosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f88e66ff97f2053201f8f68d238da6 https://doi.org/10.1242/jcs.037333 Zobrazit plný text záznamu