Genes in glucose metabolism and association with spina bifida
| Autor: | Terri M. King, Gayle H. Tyerman, Irene Townsend, Christina Davidson, Kit Sing Au, Hope Northrup, Jack M. Fletcher |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Leptin
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Candidate gene Genotype Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide White People Article Glucose Metabolism Disorder Internal medicine Hexokinase medicine Humans Genetic Predisposition to Disease Obesity Allele Genotyping Spinal Dysraphism Glucose Metabolism Disorders Genetics Glucose Transporter Type 1 Spina bifida Superoxide Dismutase Gene Expression Profiling Obstetrics and Gynecology Transmission disequilibrium test Hispanic or Latino medicine.disease Catalase Genes p53 Receptor Insulin nervous system diseases Endocrinology Receptors Leptin Female |
| Zdroj: | Reproductive sciences (Thousand Oaks, Calif.). 15(1) |
| ISSN: | 1933-7205 |
| Popis: | The authors tested single nucleotide polymorphisms (SNPs) in coding sequences of candidate genes involved in glucose metabolism and obesity for associations with spina bifida (SB). Coding SNPs on 12 candidate genes was investigated. Genotyping was performed on 507 children with SB and their parents plus anonymous control DNAs from Hispanic and Caucasian individuals. The transmission disequilibrium test was performed to test for genetic associations between transmission of alleles and SB in the offspring (P < .05). A statistically significant association between Lys481 of HK1 (G allele), Arg109Lys of LEPR (G allele), and Pro196 of GLUT1 (A allele) was found (P = .019, .039 and .040, respectively). Three SNPs on 3 genes involved with glucose metabolism and obesity may be associated with increased susceptibility to SB. |
| Databáze: | OpenAIRE |
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