Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system
| Autor: | Taylor M. Morscheck, Ming-Kuan Chyan, D. Scott Wilbur, Donald K. Hamlin, Yawen Li, Maryline G. Ferrier, Roger Wong |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
lcsh:Medicine chemistry.chemical_element 010403 inorganic & nuclear chemistry 01 natural sciences Article Bismuth Matrix (chemical analysis) 03 medical and health sciences 0302 clinical medicine lcsh:Science Astatine Packed bed Multidisciplinary Aqueous solution Molecular medicine lcsh:R Radiochemistry Thorium 0104 chemical sciences Nuclear chemistry chemistry 030220 oncology & carcinogenesis Yield (chemistry) lcsh:Q Tellurium |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-53385-x |
| Popis: | Astatine-211 is an attractive radionuclide for use in targeted alpha therapy of blood-borne diseases and micrometastatic diseases. Efficient isolation methods that can be adapted to robust automated 211At isolation systems are of high interest for improving the availability of 211At. Based on the early studies of Bochvarova and co-workers involving isolation of 211At from irradiated thorium targets, we developed a method for 211At isolation from bismuth targets using tellurium-packed columns. Dissolution of irradiated bismuth targets is accomplished using HNO3; however, 211At is not captured on the Te column material in this matrix. Our method involves slow addition of aqueous NH2OH·HCl to the Bi target dissolved in HNO3 to convert to a HCl matrix. The amount of NH2OH·HCl was optimized because (1) the quantity of NH2OH·HCl used appears to affect the radiolabeling yield of phenethyl-closo-decaborate(2-) (B10)-conjugated antibodies and (2) reducing the volume of NH2OH·HCl solution can effectively shorten the overall isolation time. A proof-of-concept semi-automated process has been demonstrated using targets containing ~0.96 GBq (~26 mCi) of 211At. High isolation yields (88–95%) were obtained. Radiochemical purity of the isolated 211At was assessed by radio-HPLC. Concentrations of Bi and Te contaminants in the 211At and the astatinated antibodies were evaluated using ICP-MS. |
| Databáze: | OpenAIRE |
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