Bifidobacterium infantis has a beneficial effect on 5-fluorouracil-induced intestinal mucositis in rats
| Autor: | Miao Yu, Hanping Shi, Ting Yang, Kaitao Yuan, W.-D. Feng, P. Chong, Conglong Xue, Honglan Yu |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Mucositis medicine.medical_specialty Side effect medicine.medical_treatment Intraperitoneal injection Microbiology Gastroenterology law.invention Rats Sprague-Dawley Probiotic law Internal medicine medicine Animals Intestinal Mucosa Chemotherapy biology business.industry Probiotics Body Weight medicine.disease Immunohistochemistry Proliferating cell nuclear antigen Treatment Outcome Fluorouracil Myeloperoxidase Immunology biology.protein Bifidobacterium business Biomarkers medicine.drug |
| Zdroj: | Beneficial microbes. 6(1) |
| ISSN: | 1876-2891 |
| Popis: | Intestinal mucositis is a common toxic side effect in cancer patients receiving high-dose chemotherapy. This study aimed to evaluate the beneficial effects of Bifidobacterium infantis in a rat model of intestinal mucositis induced by 5-fluorouracil (5-FU). Thirty male Sprague-Dawley rats were divided into three groups: control, 5-FU, and 5-FU + B. infantis. A single intraperitoneal injection of 5-FU (150 mg/kg) was used to induce intestinal mucositis. B. infantis (1×109 cfu) was administered for 11 days, starting from 7 days before 5-FU injection. Intestinal mucositis was evaluated based on body weight, villus height, immunohistological expression of proliferating cell nuclear antigen (PCNA) and nuclear factor kappa beta (NF-κB), levels of the pro-inflammatory factors interleukin 1 beta and tumour necrosis factor alpha, and myeloperoxidase (MPO) concentration. The results showed that the 5-FU + B. infantis group demonstrated a higher body weight and villus height, increased expression of PCNA, reduced expression of NF-κB and pro-inflammatory factors, and lower MPO concentration compared to the 5-FU group. These data suggest that probiotic B. infantis is effective in reducing chemotherapy-induced intestinal mucositis in rats. |
| Databáze: | OpenAIRE |
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