Inhibitory role of periventricular dopaminergic mechanisms in hemorrahge-induced vasopressin secretion in conscious rats
| Autor: | Hitoshi Hama, Ken'ichi Yamaguchi, Chieko Adachi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Vasopressin medicine.medical_specialty Vasopressins Dopamine Blood Pressure Hemorrhage Hematocrit Biology Inhibitory postsynaptic potential Internal medicine medicine Haloperidol Animals Secretion Molecular Biology Injections Intraventricular medicine.diagnostic_test General Neuroscience Dopamine antagonist Rats Inbred Strains Rats Blood pressure Endocrinology nervous system Vasopressin secretion Neurology (clinical) hormones hormone substitutes and hormone antagonists Paraventricular Hypothalamic Nucleus Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 513:335-338 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(90)90477-s |
| Popis: | Acute blood loss (16 ml/kg b. wt.) in conscious rats caused, 5 min later, increases in plasma vasopressin (AVP) concentration accompanied by reductions in arterial pressure and hematocrit. The plasma AVP response was markedly enhanced by intracerebroventricular injection (10 microliters) of a dopamine antagonist, haloperidol (0.15 mumol), which did not affect the responses of arterial pressure and hematocrit significantly. These results suggest that periventricular dopaminergic mechanisms may act to inhibit hemorrhage-induced AVP secretion. |
| Databáze: | OpenAIRE |
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