Hepatic biotransformation and choleretic effect of 7-ketolithocholic acid in the rat
| Autor: | Yuko Sato, Setsuko Kanai, Kenichi Kitani, Munetaka Nokubo |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Cholagogues and Choleretics medicine.medical_specialty Choleretic Taurine Metabolite Bicarbonate digestive system Biochemistry Bile Acids and Salts Excretion chemistry.chemical_compound Internal medicine medicine Animals Bile Chenodeoxycholate Biotransformation Ursodeoxycholic Acid Organic Chemistry Rats Inbred Strains Ursodeoxycholate Cell Biology Ursodeoxycholic acid Rats Endocrinology Liver chemistry Lithocholic Acid medicine.drug |
| Zdroj: | Lipids. 24:859-865 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/bf02535760 |
| Popis: | Hepatic biotransformation and the effect on bile flow of 7-ketolithocholic acid (7-oxo-3α-hydroxy-5β-cholan-24-oic acid), in comparison to ursodeoxycholic acid, were examined in rats under conditions of continuous infusion of solutions of sodium salts of these bile acids (1.2μmol/min/100 g body wt) for 2 hr. Both bile salts elevated the bile flow rate as well as the bile bicarbonate concentration to a similar degree. The minor difference observed was a transient (10–20 min) and subtle drop of bile flow during the first hour in rats given 7-ketolithocholate. In ursodeoxycholate infused rats, the major bile salt in the bile was its taurine conjugate, although excretion of tauroursodeoxycholate dropped considerably during the second hour. In 7-ketolithocholate infused rats, the major bile salt in the bile was again, its taurine conjugate, but ursodeoxycholate and chenodeoxycholate and their conjugates were also excreted. In contrast to ursodeoxycholate infused rats, the drop in excretion of taurine conjugates and the increase of glycine conjugates in rats infused with 7-ketolithocholate were more rapid. In rats infused with 7-ketolithocholate, excretion of ursodeoxycholate and its conjugates was significantly higher than the corresponding values for chenodeoxycholate, suggesting that 7-ketolithocholate is reduced predominatly to the 7β-epimer in this species. However, the concentration of ursodeoxycholate and its conjugates excreted into the bile in rats infused with 7-ketolithocholate was only 10% of that of rats infused with ursodeoxycholate, yet the magnitude of choleresis and the rise in bile bicarbonate concentration were similar in both experiments. Therefore, it is suggested that the bicarbonate-rich bile, induced by 7-ketolithocholate infusion, is caused mainly by 7-ketolithocholate rather than by its metabolite, ursodeoxycholate. |
| Databáze: | OpenAIRE |
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