Quantification of biofilm formation on silicone intranasal splints: Anin vitrostudy
| Autor: | Bojan Pavlović, Vojko Djukic, Ana Jotic, Dragana Božić, Neda Konstantinović, Jovica Milovanovic, Ivana Cirkovic, Slobodanka Djukic |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus 030106 microbiology Silicones Antimicrobial susceptibility Microbial Sensitivity Tests Nose medicine.disease_cause Microbiology Moraxella catarrhalis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Silicone Drug Resistance Bacterial medicine Humans In vitro study 030223 otorhinolaryngology General Immunology and Microbiology biology silicone intranasal splints Biofilm General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition biology.organism_classification quantification Anti-Bacterial Agents Multiple drug resistance Splints chemistry Biofilms biofilm formation Nasal administration |
| Zdroj: | Acta Microbiologica et Immunologica Hungarica |
| ISSN: | 1588-2640 1217-8950 |
| DOI: | 10.1556/030.63.2016.006 |
| Popis: | Objectives: Biofilms are associated with persistent infections and resistant to conventional therapeutic strategies. The aim of this study was to investigate the quantity of biofilm produced on silicone intranasal splints. Methods: Quantity of biofilm formation on silicone splints (SS) was tested on 15 strains of Staphylococcus aureus and Moraxella catarrhalis, respectively. Antimicrobial susceptibility testing was performed in accordance with European Committee on Antimicrobial Susceptibility Testing recommendations. Results: All tested strains formed different amounts of biofilm on SS: 66.7% S. aureus and 93.3% M. catarrhalis were weak biofilm producers and 33.3% S. aureus and 6.7% M. catarrhalis were moderate biofilm producers. S. aureus formed significantly higher quantity of biofilm compared with M. catarrhalis (p lt 0.05). Multidrug resistant S. aureus produced significantly higher amount of biofilm compared with non-multidrug resistant strains (p lt 0.05). Conclusion: Quantity of biofilm on SS is highly dependent on bacterial species and their resistance patterns. Future studies are needed to ascertain another therapeutic option for prophylaxis prior to SS placement. |
| Databáze: | OpenAIRE |
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