Relationships between Endogenous Sex Hormone Concentrations and Vascular Function in Postmenopausal Women
| Autor: | Paul N. Hopkins, Vincent Ricchiuti, Emily D. Szmuilowicz, Gail K. Adler, Ellen W. Seely |
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| Rok vydání: | 2007 |
| Předmět: |
Aging
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Diastole Blood Pressure Context (language use) Biochemistry Body Mass Index Cardiovascular Physiological Phenomena Renin-Angiotensin System Endocrinology Sex hormone-binding globulin Internal medicine Humans Medicine Gonadal Steroid Hormones Progesterone Aged Estradiol biology business.industry Angiotensin II Sodium Biochemistry (medical) Middle Aged Water-Electrolyte Balance medicine.disease Postmenopause Blood pressure medicine.anatomical_structure biology.protein Vascular resistance Female Vascular Resistance Hypernatremia business Blood vessel |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 92:4738-4741 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2007-1471 |
| Popis: | Differences in postmenopausal endogenous sex hormone concentrations are associated with varying risks of a growing number of common diseases. The relationships between postmenopausal endogenous sex hormone concentrations and vascular function are not well understood.We examined in postmenopausal women the relationships between endogenous sex hormone concentrations and both blood pressure (BP) and renal vascular resistance (RVR), at baseline and in response to infused angiotensin II (AngII). SUBJECTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A total of 34 hypertensive, postmenopausal women were studied in low-sodium and/or high-sodium balance. Serum estradiol, serum progesterone, BP, and RVR were measured at baseline. BP and RVR were remeasured after AngII infusion.In low-sodium balance, the increases in systolic and diastolic BP in response to infused AngII were blunted with increased serum progesterone concentrations (P0.05). The increase in RVR in response to infused AngII was also blunted with increased serum progesterone concentrations (P0.005). The relationships between progesterone concentration and vascular response to AngII were independent of age, body mass index, and estradiol concentration. There were no significant correlations between estradiol concentration and BP or RVR response to AngII. There were no significant correlations between sex hormone concentrations and baseline BP or RVR. In high-sodium balance, there were no significant associations between sex hormone concentrations and vascular measures.In postmenopausal women in low-sodium balance, the pressor and renovascular responses to AngII are blunted with increased endogenous progesterone concentrations. Our findings suggest a role for endogenous progesterone in modulating vascular function, even within the low postmenopausal range. |
| Databáze: | OpenAIRE |
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