Clinical, Microbiologic, and Biochemical Effects of Subgingival Administration of a Xanthan-Based Chlorhexidine Gel in the Treatment of Periodontitis: A Randomized Multicenter Trial

Autor: Filippo Graziani, Gilberto Sammartino, Luca Lisanti, Giuseppe Spoto, Andrea Pilloni, Beatrice Femminella, Michele Paolantonio, Raffaele Piccolomini, Giorgio Perfetti, Giuseppe Perinetti, Domenico D'Archivio, Letizia Perillo, Simonetta D'Ercole, Stefano Tetè
Přispěvatelé: Paolantonio, M, D'Ercole, S, Pilloni, A, D'Archivio, D, Lisanti, L, Graziani, F, Femminella, B, Sammartino, G, Perillo, Letizia, Tetè, S, Perfetti, G, Spoto, G, Piccolomini, R, Perinetti, G., Perillo, L, Perinetti, Giuseppe, Paolantonio, M., D'Ercole, S., Pilloni, A., D'Archivio, D., Lisanti, L., Graziani, F., Femminella, B., Sammartino, Gilberto, Perillo, L., Tetè, S., Perfetti, G., Spoto, G., Piccolomini, R.
Rok vydání: 2009
Předmět:
Adult
Male
periodontology
Bleeding on probing
Colony Count
Microbial
Dental Plaque
Dentistry
clinica trial
Root Planing
law.invention
Young Adult
Scaling and root planing
Randomized controlled trial
law
Multicenter trial
Periodontal Attachment Loss
medicine
periodontiti
Humans
Periodontal Pocket
Single-Blind Method
Periodontitis
Drug Carriers
Bacteria
business.industry
Chlorhexidine
Dental Plaque Index
Polysaccharides
Bacterial
Gingival Crevicular Fluid
Middle Aged
Alkaline Phosphatase
medicine.disease
Chronic periodontitis
chlorhexidine
drug delivery systems
periodontitis/therapy
randomized clinical trial
xanthan gum
Concomitant
Chronic Periodontitis
Anti-Infective Agents
Local
Dental Scaling
Periodontics
Female
Periodontal Index
medicine.symptom
chlorexidine
Gingival Hemorrhage
business
Gels
Follow-Up Studies
medicine.drug
Zdroj: Journal of Periodontology. 80:1479-1492
ISSN: 1943-3670
0022-3492
DOI: 10.1902/jop.2009.090050
Popis: Background: The use of locally delivered antibacterials containing chlorhexidine (CHX) was proposed to improve the effectiveness of non-surgical periodontal treatment. The present multicenter randomized study investigated the effects of a xanthan-based chlorhexidine (Xan-CHX) gel used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Methods: Ninety-eight systemically healthy subjects with moderate to advanced periodontitis were recruited in four centers (59 females and 39 males; aged 24 to 58 years). For each subject, two experimental sites located in two symmetric quadrants were chosen with probing depths (PD) ‡5 mm and positive for bleeding on probing (BOP). These two sites were randomized at the split-mouth level with one receiving a single SRP treatment and the other receiving a single SRP + Xan-CHX gel treatment. Supragingival plaque, modified gingival index, PD, clinical attachment level (CAL), and BOP were evaluated at baseline (prior to any treatment) and after 3 and 6 months. At the same times, subgingival microbiologic samples and gingival crevicular fluid (GCF) were collected for the analysis of total bacterial counts (TBCs), including the identification of eight putative periodontopathogens, and alkaline phosphatase (ALP) activity, respectively. Results: The Xan-CHX treatment group showed greater improvements compared to the SRP group for PD and CAL at 3a nd 6m onths (P
Databáze: OpenAIRE
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