Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies
| Autor: | Phillip R. Kramer, Larry L. Bellinger, Yuanyuan Tang, Sufang Liu, Ying Xing, Feng Tao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Central nervous system
Stimulation Review Optogenetics migraine-like pain lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Medicine neuronal excitation neuronal inhibition optogenetics lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology 0303 health sciences business.industry General Neuroscience Perspective (graphical) medicine.disease Neuromodulation (medicine) medicine.anatomical_structure Neuronal circuits Migraine neuronal activity modulation Animal studies business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Sciences Brain Sciences, Vol 9, Iss 2, p 26 (2019) |
| ISSN: | 2076-3425 |
| Popis: | Optogenetic manipulation is uniquely useful in unraveling the functional organization of neuronal circuits in the central nervous system by enabling reversible gain- or loss-of-function of discrete populations of neurons within restricted brain regions. This state-of-the-art technology can produce circuit-specific neuromodulation by overexpressing light-sensitive proteins (opsins) in particular cell types of interest. Here, we discuss the principle of optogenetic manipulation and its application in pain research using animal models, and we also discuss how to potentially use optogenetic stimulation in the treatment of migraine headache in the future. |
| Databáze: | OpenAIRE |
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