A Fatal Overdose of Arginine Hydrochloride
| Autor: | James M. Gerard, Atchawee Luisiri |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Resuscitation
Arginine Hyperkalemia Health Toxicology and Mutagenesis Metabolic alkalosis Toxicology Drug overdose Fatal Outcome Cerebellum Pons medicine Humans Medication Errors Growth Disorders business.industry Infant Metabolic acidosis medicine.disease Heart Arrest Growth Hormone Anesthesia Myelinolysis Central Pontine Toxicity Female Drug Overdose medicine.symptom Acidosis Tomography X-Ray Computed Hyponatremia business |
| Zdroj: | Journal of Toxicology: Clinical Toxicology. 35:621-625 |
| ISSN: | 0731-3810 |
| DOI: | 10.3109/15563659709001243 |
| Popis: | Case Report: Arginine hydrochloride is used both diagnostically to test for growth hormone deficiency and therapeutically for treatment of metabolic alkalosis. We describe a 21-month-old girl who developed cardiopulmonary arrest following an accidental overdose of arginine hydrochloride. The patient developed acute metabolic acidosis and transient, but severe, hyponatremia. Thirty-six hours after successful resuscitation, she developed fatal central pontine and extrapontine myelinolysis. Unlike previous reports of arginine toxicity, our patient showed no evidence of hyperkalemia. This case illustrates a previously unreported mechanism of arginine hydrochloride toxicity. |
| Databáze: | OpenAIRE |
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