Francisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production
| Autor: | Jorma Ilonen, Heljä-Marja Surcel, E Herva, K Poikonen |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
T-Lymphocytes
T cell Immunology Immunoglobulins Human leukocyte antigen Microbiology Immunoglobulin G Epitopes Interferon-gamma Antigen HLA-DQ Antigens medicine Humans Interferon gamma Francisella tularensis HLA-DQ Antigen biology Histocompatibility Antigens Class II HLA-DR Antigens biology.organism_classification Virology Molecular biology Clone Cells Infectious Diseases medicine.anatomical_structure biology.protein Interleukin-2 Parasitology Antibody Research Article medicine.drug |
| Zdroj: | Infection and Immunity. 57:2906-2908 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.57.9.2906-2908.1989 |
| Popis: | T-cell clones (TLC) were established from a Francisella tularensis-vaccinated subject in order to study the cells responsive for cell-mediated immunity against F. tularensis. All the clones were human leukocyte antigen (HLA) class II restricted to one of the HLA-DR specificities of the original donor. The TLC cells were CD4+ and produced interleukin-2 and gamma interferon after stimulation with specific antigen. Seven of the eight clones tested assisted in the production of immunoglobulin G (IgG), IgA, and IgM antibodies. |
| Databáze: | OpenAIRE |
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