Xanthine oxidase activity in type 2 diabetic Nigerians
| Autor: | Donatus Ozuruoke, Alfred Azenabor, Esther Ngozi Adejumo, Rachel Erivona, Rosemary Azenabor |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine Xanthine Oxidase medicine.medical_specialty Endocrinology Diabetes and Metabolism Nigeria Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Xanthine oxidase Aged Glycemic Glycated Hemoglobin medicine.diagnostic_test business.industry Incidence General Medicine Middle Aged Prognosis medicine.disease Uric Acid Oxidative Stress C-Reactive Protein Cross-Sectional Studies 030104 developmental biology Fructosamine Endocrinology Diabetes Mellitus Type 2 chemistry Case-Control Studies Erythrocyte sedimentation rate Uric acid Female Lipid Peroxidation Hemoglobin business Biomarkers Follow-Up Studies |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13:2021-2024 |
| ISSN: | 1871-4021 |
| Popis: | Aim This study evaluated the activity of xanthine oxidase in Nigerians with type 2 diabetic mellitus as well as its relationship with lipid peroxidation, inflammatory bio markers and glycemic control indices. Methods Two hundred and thirty seven (237) subjects, comprising of one hundred and fifty seven (157) DM subjects and eighty (80) aged matched controls participated in this study. Blood samples were collected from the participants for the estimations of xanthine oxidase activity, uric acid, malon diadehyde (MDA), erythrocyte sedimentation rate (ESR), high sensitive c – reactive protein (hs CRP), glucose, fructosamine and glycosylated hemoglobin by standard methods. Results The results of this study showed a significantly increased activity of xanthine oxidase in DM (0.044 ± 0.05μ/mg) compared with apparently healthy controls (0.028 ± 0.00 μ/mg). The mean plasma levels of MDA (42.40 ± 2.50μmol/l) and uric acid (7.22 ± 0.20 mg/dl) in DM were significantly higher (p ≤ 0.05) than healthy non DM group. The mean levels of hs CRP in DM (4.09 ± 0.91μg/ml) was significantly higher than controls (1.30 ± 0.50μg/ml, p = 0.009). While no association of xanthine oxidase was observed with glycemic control indices and hs CRP, a negative association of xanthine oxidase was observed with MDA (r = −0.514, p = 0.000). Conclusion Increased activity of xanthine oxidase in DM was associated with increased lipid peroxidation and could be a salient entity towards the onset on complications. |
| Databáze: | OpenAIRE |
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