| Autor: |
Giannico, Francesco, Massari, Serafina, Jambrenghi, Anna Caputi, Soriano, Adriano, Pala, Angela, Linguiti, Giovanna, Ciccarese, Salvatrice, Antonacci, Rachele |
| Rok vydání: |
2020 |
| DOI: |
10.6084/m9.figshare.12940216.v1 |
| Popis: |
Additional file 4: Figure S1. Description of the goat TRBV genes. The IMGT Protein display of the goat TRBV genes. The deduced amino acid sequences of the goat TRBV genes were manually aligned according to IMGT unique numbering for the V-REGION [33] to maximize homology. Only functional genes, ORF and in-frame pseudogenes are shown. All sequences exhibit the typical framework regions (FR) and complementarity determining regions (CDR) and the four amino acids (depicted and indicated in bold): cysteine 23 (1st-CYS) in FR1-IMGT, tryptophan 41 (CONSERVED-TRP) in FR2-IMGT, hydrophobic (here L and M) 89, and cysteine 104 (2nd-CYS) in FR3-IMGT, with the exception of TRBV6–20 and TRBV6–21 that lack the CONSERVED-TRP and the 2nd-CYS, respectively. Conversely, CDR-IMGT vary in amino acid composition and length. The description of the strands and loops and of the FR-IMGT and CDR-IMGT is according to the IMGT unique numbering for V-REGION [33]. The amino acid length of the CDR-IMGT AA is also indicated in square brackets. (B-D), nucleotide and deduced amino acid sequences of the TRBD, TRBJ and TRDC genes. The consensus sequence of the heptamer and nonamer is provided at the top of the figure and is underlined. The numbering adopted for the gene classification is reported on the left of each gene. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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