CT- and MRI-based gross target volume comparison in vestibular schwannomas
| Autor: | N.V.N. Madusudan Sresty, Shabbir Ahmad, Sunil Dutt Sharma, Rohith Singareddy, Amit Kumar, Harjot Kaur Bajwa, Dileep Gudipudi, Alluri Krishnam Raju, Bhudevi Soubhagya N. Kulkarni, Mukka Chandrashekhar |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment Planning target volume Gross Target Volume Magnetic resonance imaging Left sided 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine Oncology Sørensen–Dice coefficient 030220 oncology & carcinogenesis Vestibular Schwannomas medicine Radiology Nuclear Medicine and imaging Radiology Original Research Article Nuclear medicine business Prospective cohort study Mathematics |
| Popis: | Aim This study represents an enumeration and comparison of gross target volumes (GTV) as delineated independently on contrast-enhanced computed tomography (CT) and T1 and T2 weighted magnetic resonance imaging (MRI) in vestibular schwannomas (VS). Background Multiple imaging in radiotherapy improves target localization. Methods and materials 42 patients of VS were considered for this prospective study with one patient showing bilateral tumor. The GTV was delineated separately on CT and MRI. Difference in volumes were estimated individually for all the 43 lesions and similarity was studied between CT and T1 and T2 weighted MRI. Results The male to female ratio for VS was found to be 1:1.3. The tumor was right sided in 34.9% and left sided in 65.1%. Tumor volumes (TV) on CT image sets were ranging from 0.251 cc to 27.27 cc. The TV for CT, MRI T1 and T2 weighted were 5.15 ± 5.2 cc, 5.8 ± 6.23 cc, and 5.9 ± 6.13 cc, respectively. Compared to MRI, CT underestimated the volumes. The mean dice coefficient between CT versus T1 and CT versus T2 was estimated to be 68.85 ± 18.3 and 66.68 ± 20.3, respectively. The percentage of volume difference between CT and MRI (%VD: mean ± SD for T1; 28.84 ± 15.0, T2; 35.74 ± 16.3) and volume error (%VE: T1; 18.77 ± 10.1, T2; 23.17 ± 13.93) were found to be significant, taking the CT volumes as the baseline. Conclusions MRI with multiple sequences should be incorporated for tumor volume delineation and they provide a clear boundary between the tumor and normal tissue with critical structures nearby. |
| Databáze: | OpenAIRE |
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