Autor: |
Sebabrata Mahapatra, Kristofor J. Webb, Reem Almubarak, Samantha Bokatzian, John T. Belisle, Diane V. Havlir, Anne F Luetkemeyer, Michelle A. Kendall, Laura Hovind, Barbara Graham, Carlos A.M. Silva, Marisa Harton, Laura V. Ashton, Mary Ann De Groote |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases International Journal of Infectious Diseases, Vol 84, Iss, Pp 30-38 (2019) |
ISSN: |
1201-9712 |
Popis: |
Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS. Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Molecular features with p |
Databáze: |
OpenAIRE |
Externí odkaz: |
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