A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome

Autor: Sebabrata Mahapatra, Kristofor J. Webb, Reem Almubarak, Samantha Bokatzian, John T. Belisle, Diane V. Havlir, Anne F Luetkemeyer, Michelle A. Kendall, Laura Hovind, Barbara Graham, Carlos A.M. Silva, Marisa Harton, Laura V. Ashton, Mary Ann De Groote
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Human immunodeficiency virus (HIV)
HIV Infections
Pilot Projects
urologic and male genital diseases
Bioinformatics
medicine.disease_cause
chemistry.chemical_compound
0302 clinical medicine
Immune Reconstitution Inflammatory Syndrome
Tandem Mass Spectrometry
Medicine
030212 general & internal medicine
Chromatography
Liquid
Pulmonary
General Medicine
female genital diseases and pregnancy complications
3. Good health
AIDS
Infectious Diseases
Medical Microbiology
Public Health and Health Services
HIV/AIDS
Female
Arachidonic acid
Infection
Adult
Microbiology (medical)
Tuberculosis
Biosignature features
Anti-HIV Agents
Clinical Trials and Supportive Activities
030106 microbiology
Microbiology
Article
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Rare Diseases
Metabolomics
Acquired immunodeficiency syndrome (AIDS)
Immune reconstitution inflammatory syndrome
Clinical Research
Humans
lcsh:RC109-216
cardiovascular diseases
Tuberculosis
Pulmonary
urogenital system
business.industry
fungi
IRIS
medicine.disease
Sphingolipid
Clinical trial
Emerging Infectious Diseases
Good Health and Well Being
chemistry
business
Chromatography
Liquid
Zdroj: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
International Journal of Infectious Diseases, Vol 84, Iss, Pp 30-38 (2019)
ISSN: 1201-9712
Popis: Background: Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS. Methods: Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Molecular features with p
Databáze: OpenAIRE
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