Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid
| Autor: | João Luis Callegari Lopes, Norberto Peporine Lopes, Denise Brentan Silva, Lucas Miranda Marques, Anderson Rodrigo Moraes de Oliveira, Daniel R. Callejon, Fernando Armani Aguiar, Thais Guaratini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Drug metabolism
Cytochrome P450 lcsh:RS1-441 Fabaceae CYP450 Metabolism Biology Pharmacology biology.organism_classification lcsh:Pharmacy and materia medica Pharmacology Toxicology and Pharmaceutics(all) Biotransformation Erythraline visual_art ANSIOLÍTICOS visual_art.visual_art_medium biology.protein Microsome Microsomal model Bark General Pharmacology Toxicology and Pharmaceutics Erythrina |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 25, Iss 5, Pp 529-532 (2015) Revista Brasileira de Farmacognosia, Volume: 25, Issue: 5, Pages: 529-532, Published: OCT 2015 Revista Brasileira de Farmacognosia, Vol 25, Iss 5, Pp 529-532 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The genus Erythrina, Fabaceae, is widely distributed in tropical and subtropical regions. Their flowers, fruits, seeds and bark are frequently used in folk medicine for its effects on the central nervous system such as anticonvulsant, antidepressant, analgesic, sedative, and hypnotic effects. Erythraline has been reported as one of the active compounds from Erythrina, but until now there are no pharmacokinetics data about this compound and only few results showing a putative metabolism were reported. To improve the information about erythraline metabolism, this article reports and discusses, for the first time, the in vitro metabolism biotransformation of erythraline by cytochrome P450 enzymes. Keywords: Fabaceae, Erythraline, CYP450, Drug metabolism, Microsomal model |
| Databáze: | OpenAIRE |
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