Evaluation of various biomarkers as potential mediators of the association between Δ5 desaturase, Δ6 desaturase, and stearoyl-CoA desaturase activity and incident type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition–Potsdam Study
| Autor: | Eugene Jansen, Simone Jacobs, Matthias B. Schulze, Katja Schiller, Janine Kröger, Heiner Boeing |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Fatty Acid Desaturases Male medicine.medical_specialty alpha-2-HS-Glycoprotein Medicine (miscellaneous) Type 2 diabetes Linoleoyl-CoA Desaturase White People Body Mass Index Delta-5 Fatty Acid Desaturase Surveys and Questionnaires Internal medicine medicine Humans Prospective Studies Triglycerides Proportional Hazards Models chemistry.chemical_classification Nutrition and Dietetics biology Adiponectin Incidence Cholesterol HDL Fatty liver nutritional and metabolic diseases Fatty acid Alanine Transaminase gamma-Glutamyltransferase Middle Aged medicine.disease European Prospective Investigation into Cancer and Nutrition Europe Fatty Liver Stearoyl-CoA Desaturase C-Reactive Protein Cross-Sectional Studies Endocrinology Diabetes Mellitus Type 2 chemistry Alanine transaminase biology.protein Female Waist Circumference Biomarkers Dyslipidemia Follow-Up Studies |
| Zdroj: | The American Journal of Clinical Nutrition. 102:155-164 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.114.102707 |
| Popis: | Background: An association between desaturase activity and risk of type 2 diabetes (T2D) has been found in epidemiologic studies, but little is known about potential mediators of this association. Objective: We aimed to investigate the potential role of diabetesrelated biomarkers as mediators of the association between estimated D5 desaturase (D5D), D6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) activity and T2D risk. Design: We analyzed a case-cohort study (subcohort: n = 1533; verified incident T2D cases: n = 400), nested within the European Prospective Investigation into Cancer and Nutrition–Potsdam Study involving 27,548 middle-aged participants. We evaluated the impact of adjustment for several T2D-related biomarkers reflecting liver fat accumulation [reflected by g-glutamyltransferase (GGT), alanine transaminase (ALT), fetuin-A, and the algorithm-based fatty liver index (FLI)], dyslipidemia (high-density lipoprotein cholesterol, triglycerides), inflammation [C-reactive protein (CRP)], and adiponectin on the association between D5D, D6D, and SCD activity, estimated with fatty acid product-to-precursor ratios derived from erythrocyte membrane proportions, and T2D risk. Results: Estimated D5D activity was inversely associated with T2D risk, whereas D6D and SCD activities were positively associated with risk of T2D [HRs (95% CIs) (highest vs. lowest tertile): 0.51 (0.36, 0.73), 1.68 (1.18, 2.39), and 1.82 (1.29, 2.58), respectively]. The association between estimated D5D, D6D, and SCD activities and risk of T2D was statistically significantly and markedly attenuated after adjustment for the FLI and, to a lesser extent, after adjustment for triglycerides, whereas adjustment for other desaturase-associated biomarkers (CRP, fetuin-A, ALT, and GGT) did not lead to appreciable attenuations. Conclusions: Liver fat accumulation, as reflected by the FLI, and dyslipidemia, as reflected by triglycerides, may partly explain the association between estimated D5D, D6D, and SCD activity and T2D risk. Am J Clin Nutr 2015;102:155–64. |
| Databáze: | OpenAIRE |
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