High sensitivity label-free detection of HER2 using an Al–GaN/GaN high electron mobility transistor-based biosensor

Autor:	Shivanshu Mishra, Pharyanshu Kachhawa, Amber Kumar Jain, Rajiv Ranjan Thakur, Nidhi Chaturvedi
Rok vydání:	2022
Předmět:	Transistors Electronic Biomedical Engineering Electrons Bioengineering Biosensing Techniques Gold Sulfhydryl Compounds General Chemistry Aluminum Compounds Biochemistry Sulfur
Zdroj:	Lab on a Chip. 22:4129-4140
ISSN:	1473-0189 1473-0197
DOI:	10.1039/d2lc00349j
Popis:	This work reports rapid, label-free and specific detection of the HER2 antigen using a gallium nitride (GaN) high electron mobility transistor (HEMT). Thiol-based chemistry has been utilized to immobilize the corresponding HER2 antibody in the sensing area of the sensor. The formation of a gold-sulfur complex has been confirmed through Raman spectroscopy, giving a peak at around a wavelength of 260 cm
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e5003241f2c0a01debcc1cb53f4008 https://doi.org/10.1039/d2lc00349j Zobrazit plný text záznamu