Chloroformic and Methanolic Extracts of Olea europaea L. Leaves Present Anti-Inflammatory and Analgesic Activities

Autor:	R Chebbi Mahjoub, F. Khemiss, Abderrahman Bouraoui, A. Dellaï, M. Khemiss, M. Dhidah
Rok vydání:	2011
Předmět:	Analgesic effect Article Subject biology Traditional medicine medicine.drug_class business.industry Analgesic Intestinal spasms Body weight biology.organism_classification Anti-inflammatory Olea medicine business Research Article Paw edema
Zdroj:	ISRN Pharmacology
ISSN:	2090-5173 2090-5165
DOI:	10.5402/2011/564972
Popis:	Olea europaea L. is used in traditional medicine in the Mediterranean areas. Its natural products are used in the treatment of different disorders, like fighting fever and some infectious diseases such as malaria, the treatment of arrhythmia, and relief of intestinal spasms. The aim of the current study is to investigate the possible anti-inflammatory and anatinociceptive effects of methanol and chloroformic extracts prepared from leaves of Olea europaea L. The anti-inflammatory and antinociceptive effects of the different extracts of Olea europaea leaves were assessed after intraperitoneal administration into rats and mice, using the carrageenan-induced paw edema model in rats to test the anti-inflammatory effect and the acetic acid-induced writhing in mice to test the analgesic effect. The chloroformic and methanolic leaves extracts, studied at the doses of 50, 100, and 200 mg/kg (Body Weight: BW), exhibited significant dose-dependent anti-inflammatory and analgesic activities. Based on the results obtained, it can be concluded that Olea europaea leaves extracts have anti-inflammatory and antinociceptive effects.
Databáze:	OpenAIRE
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