Amino-acid-enriched cereals ready-to-use therapeutic foods (RUTF) are as effective as milk-based RUTF in recovering essential amino acid during the treatment of severe acute malnutrition in children: An individually randomized control trial in Malawi

Autor: Hitoshi Murakami, Chrissy Banda, Chie Furuta, Steve Collins, Paluku Bahwere, Peter Akomo, Elizabeth Maganga, Keiko Matsunaga, Sylvester Kathumba, Wataru Sato, Kate Sadler
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Malawi
Physiology
Psychologie appliquée
lcsh:Medicine
Protein Synthesis
Biochemistry
law.invention
chemistry.chemical_compound
0302 clinical medicine
Methionine
Randomized controlled trial
law
Blood plasma
Medicine and Health Sciences
030212 general & internal medicine
Amino Acids
lcsh:Science
Essential amino acid
chemistry.chemical_classification
Multidisciplinary
Organic Compounds
Chemical Synthesis
Eukaryota
Sciences bio-médicales et agricoles
Plants
Amino acid
Body Fluids
Chemistry
Milk
Blood
Experimental Organism Systems
Child
Preschool
Physical Sciences
Food
Fortified
Amino Acid Analysis
Female
Anatomy
Biologie
Research Article
medicine.medical_specialty
Biosynthetic Techniques
Severe Acute Malnutrition
Research and Analysis Methods
Blood Plasma
Beverages
03 medical and health sciences
Model Organisms
Leucine
Plant and Algal Models
Internal medicine
medicine
Sulfur Containing Amino Acids
Animals
Humans
Grasses
Molecular Biology Techniques
Molecular Biology
Nutrition
Molecular Biology Assays and Analysis Techniques
030109 nutrition & dietetics
business.industry
Organic Chemistry
Malnutrition
lcsh:R
Chemical Compounds
Organisms
Biology and Life Sciences
Proteins
Infant
medicine.disease
Diet
Maize
chemistry
Aliphatic Amino Acids
Therapeutic food
lcsh:Q
Amino Acids
Essential
business
Edible Grain
Zdroj: PLoS ONE, Vol 13, Iss 8, p e0201686 (2018)
PLoS ONE
PloS one, 13 (8
ISSN: 1932-6203
Popis: Background Ready-to-use therapeutic food (RUTF) is used to treat children suffering from severe acute malnutrition (SAM). Standard RUTF uses milk as the primary protein source, which makes the product expensive, and given the high worldwide SAM burden, having a less expensive effective alternative is a public health priority. Objective The objective of this study was to evaluate whether newly developed amino acid-enriched milk-free RUTF (FSMS-RUTF) or amino acid-enriched low-milk RUTF (MSMS-RUTF) treatment could replenish plasma amino acids to levels comparable to those following standard peanut-milk RUTF (PM-RUTF) treatment and to improve understanding of the effects of treatment on anthropometric measurements. A secondary analysis was performed to test the noninferiority hypothesis of plasma essential amino acid (EAA) levels. Methods Plasma EAA levels were measured in a nonblinded, 3-arm, parallel-group simple randomized controlled trial conducted in Malawi to examine the efficacy of FSMS-RUTF, MSMSRUTF and PM-RUTF in the treatment of SAM in 2 groups of children aged 6-23 and 24-59 months (mo). Sample size calculations were performed based on the previous our study. A noninferiority margin was set at -25% of the PM-RUTF arm at discharge. Results The relative values of the differences (95% CI) in plasma EAA levels between PM-RUTF treatment and FSMS-RUTF and MSMS-RUTF treatments at discharge were -7.9% (-18.6, 2.8) and 9.8% (0.2, 19.5), respectively, in children aged 6-23 mo, while in those aged 24-59 mo, the difference values were 17.8% (1.6, 34.1) and 13.6% (-2.8, 29.9), respectively. Conclusion At discharge, the plasma EAA concentrations in 6-59-mo-old SAM children treated with FSMS-RUTF and MSMS-RUTF were not less than those of children treated with PM-RUTF. These findings indicate that treatment with either of the 3 RUTFs was associated with adequate protein synthesis and that all the formulations provided sufficient functional metabolites of plasma amino acids to support nutritional recovery from SAM.
SCOPUS: ar.j
info:eu-repo/semantics/published
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje