A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial
| Autor: | Yi Guo, Peiwen Zhang, Honghui Guo, Longying Zha, Yongji Liu, Wenhua Ling |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Inflammation Pharmacology Placebo medicine.disease_cause law.invention Anthocyanins Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Randomized controlled trial Risk Factors law Humans Medicine Dosing Young adult 030109 nutrition & dietetics Nutrition and Dietetics business.industry food and beverages Oxidative Stress chemistry Anthocyanin Dietary Supplements medicine.symptom business Biomarkers Oxidative stress |
| Zdroj: | Nutrition. 74:110745 |
| ISSN: | 0899-9007 |
| Popis: | Objectives Anthocyanins derived from different plant sources have been found to possess a variety of health-promoting effects, including antiinflammatory properties and protection from oxidative stress. The aim of this study was to investigate the dose-response relationship between anthocyanins and metabolic risk factors as well as inflammatory and oxidative biomarkers in healthy adult volunteers. Methods We conducted a randomized, double-blind, placebo-controlled trial, which included an increasing dosing schedule of 20, 40, 80, 160, and 320 mg of purified anthocyanins or placebo. Participants (n = 111) were administered either agent for 14 consecutive days. Results No significant differences in either baseline characteristics or daily intake of dietary nutrients were detected between the experimental and control groups. After anthocyanin supplementation, there was a significant difference in adjusted fasting plasma glucose levels. The group receiving 80 mg/d of anthocyanin had the lowest baseline-adjusted fasting plasma glucose when compared with placebo (F = 3.556, P = 0.007). Logarithmically adjusted plasma interleukin-10 levels were negatively correlated with increasing anthocyanin dose (F = 2.738, P = 0.025). Similarly, 8-iso-prostaglandin F2α levels decreased with increasing anthocyanins dose (F = 3.513, P = 0.009). Conclusions Taken together, our results suggest that anthocyanin supplementation at a dose greater than 80 mg/d is an effective antioxidant and antiinflammatory agent in healthy young adults. |
| Databáze: | OpenAIRE |
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