Upper extremity deep vein thrombosis after suspension of progesterone-only oral treatment
| Autor: | Assunta Orecchioni, Mario Lapecorella, Guglielmo Mariani, Luigi Dell'Orso |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Deep vein Thrombophilia Gastroenterology Contraceptives Oral Hormonal Upper Extremity Risk Factors Oral administration Internal medicine medicine Coagulopathy Humans Point Mutation Risk factor Methylenetetrahydrofolate Reductase (NADPH2) Progesterone Venous Thrombosis Progestogen business.industry Hematology General Medicine Middle Aged medicine.disease Thrombosis Surgery Venous thrombosis medicine.anatomical_structure Female Prothrombin business |
| Zdroj: | Blood Coagulation & Fibrinolysis. 18:513-517 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/mbc.0b013e3281a3bed8 |
| Popis: | The intake of steroid hormone contraceptives is a strong and independent risk factor for venous thromboembolism. Several studies have assessed an increased risk of venous thromboembolism in women using oral contraceptives who are carriers of the G20210A mutation in the prothrombin gene. Most trials evaluating the thrombotic risk of oral contraceptives are based on combined oral preparations, but only a few focus on progestogen-only oral preparations. Results from such studies are conflicting and globally assess the thrombotic risk, ranging from modest to slightly increased. Furthermore, little is known about the relationship between the C677T mutation in the methylenetetrahydrofolate reductase gene and the progestogen-based preparations. Herewith we report the case of a 49-year-old woman with a complex genetic thrombosis risk factor who had taken oral progesterone for 15 months without any complication, but then experienced severe left upper extremity deep vein thrombosis 2 months after the drug suspension. |
| Databáze: | OpenAIRE |
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