A preliminary report on the biocompatibility of photopolymerizable semi-interpenetrating anhydride networks
| Autor: | Venkatram Prasad Shastri, Peter J. Tarcha, Robert Langer, Robert F. Padera |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Materials science
Biocompatibility Photochemistry Biophysics Connective tissue Biocompatible Materials Pilot Projects Bioengineering Fibrous capsule Anhydrides Biomaterials Tissue engineering Preliminary report Absorbable Implants Materials Testing medicine Animals Foreign-Body Reaction Bone cement Rats medicine.anatomical_structure Connective Tissue Mechanics of Materials Drug delivery Ceramics and Composites Feasibility Studies Porosity Subcutaneous tissue Biomedical engineering |
| Zdroj: | Biomaterials. 25:715-721 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/s0142-9612(03)00563-5 |
| Popis: | A new family of poly(anhydrides) (PA) has been developed which can be cured photochemically to produce degradable networks. These degradable anhydride networks may be useful in orthopaedics as bone cements and as matrices for drug delivery. This system, which is a semi-interpenetrating network (semi-IPN), has been evaluated for biocompatibility in subcutaneous tissue in rats and appears to undergo degradation primarily by surface erosion. The inflammatory response to the semi-IPN implants was minimal at both short (3 and 6 weeks) and long (28 weeks) time points and the fibrotic response was largely absent throughout the duration of this study. Furthermore, the OrthoCure™ implant material integrated well with the surrounding tissue and was invaded with vascularized connective tissue. For reference, linear PA controls were tested and showed a foreign body response culminating in the formation of relatively avascular fibrous capsule several cell layers thick, which became thicker over time, a response similar to what is typically observed in FDA approved implantable polymeric device systems. |
| Databáze: | OpenAIRE |
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