GlycA, a Pro-Inflammatory Glycoprotein Biomarker, and Incident Cardiovascular Disease: Relationship with C-Reactive Protein and Renal Function

Autor: Eke G. Gruppen, Robin P. F. Dullaart, Margery A. Connelly, James D. Otvos, Stephan J. L. Bakker, Ineke J. Riphagen
Přispěvatelé: Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC)
Rok vydání: 2015
Předmět:
Male
CHRONIC KIDNEY-DISEASE
Magnetic Resonance Spectroscopy
PREDICTION
lcsh:Medicine
GLOMERULAR-FILTRATION-RATE
Gastroenterology
chemistry.chemical_compound
Risk Factors
Medicine
Prospective Studies
lcsh:Science
Prospective cohort study
Netherlands
GENERAL-POPULATION
RISK
Multidisciplinary
biology
Incidence
Hazard ratio
Middle Aged
C-Reactive Protein
Cardiovascular Diseases
Biomarker (medicine)
Female
Kidney Diseases
medicine.symptom
CREATININE
Glomerular Filtration Rate
Research Article
Adult
medicine.medical_specialty
ALBUMINURIA
Renal function
MECHANISMS
Sex Factors
Internal medicine
Humans
cardiovascular diseases
Aged
Glycoproteins
Inflammation
Creatinine
Proportional hazards model
business.industry
GLYCOSYLATION
lcsh:R
C-reactive protein
Endocrinology
chemistry
COLLABORATIVE METAANALYSIS
Albuminuria
biology.protein
lcsh:Q
business
Biomarkers
Zdroj: PLoS ONE, 10(9):e0139057. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 10, Iss 9, p e0139057 (2015)
PLoS ONE
ISSN: 1932-6203
Popis: ObjectiveGlycA is a novel nuclear magnetic resonance spectroscopy-measured biomarker of systemic inflammation. We determined whether GlycA is associated with incident cardiovascular disease (CVD) in men and women, examined whether this association with CVD is modified by renal function, and compared this association with high sensitivity C-reactive protein (hsCRP).Research design and methods A prospective cohort study was performed among 4,759 subjects (PREVEND study) without a history of CVD and cancer. Incident CVD was defined as the combined endpoint of cardiovascular morbidity and mortality. Cox regression analyses were used to examine associations of baseline GlycA and hsCRP with CVD.Results298 first CVD events occurred during a median follow-up of 8.5 years. After adjustment for clinical and lipid measures the hazard ratio (HR) for CVD risk in the highest GlycA quartile was 1.58 (95% CI, 1.05-2.37, P for trend = 0.004). This association was similar after further adjustment for renal function (estimated glomerular filtration rate and urinary albumin excretion). After additional adjustment for hsCRP, GlycA was still associated with incident CVD (HR: 1.16 per SD change (95% CI, 1.01-1.33), P = 0.04). Similar results were obtained for hsCRP (HR per SD change after adjustment for GlycA: 1.17 (95% CI 1.17 (95% CI, 1.01-3.60), P = 0.04). CVD risk was highest in subjects with simultaneously higher GlycA and hsCRP (fully adjusted HR: 1.79 (95% CI, 1.31-2.46), PConclusionGlycA is associated with CVD risk in men and women, independent of renal function. The association of GlycA with incident CVD is as strong as that of hsCRP.
Databáze: OpenAIRE
Externí odkaz: