The influence of the number of lymph nodes removed on the accuracy of a newly proposed N descriptor classification in patients with surgically-treated lung cancer
| Autor: | Marcin M Cackowski, Katarzyna Woźnica, Dariusz Dziedzic, Grzegorz M Gryszko, Tadeusz Orłowski, Marcin Zbytniewski |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Databases Factual medicine.medical_treatment 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung medicine Humans In patient Lung cancer Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Skip metastasis business.industry Middle Aged medicine.disease Survival Rate Oncology Cardiothoracic surgery 030220 oncology & carcinogenesis Lymph Node Excision Female Surgery Lymphadenectomy Lymph Nodes Poland Non small cell Lymph Radiology business |
| Zdroj: | Surgical Oncology. 37:101514 |
| ISSN: | 0960-7404 |
| Popis: | The International Association for the Study of Lung Cancer has proposed a new classification of N descriptor based on the number of metastatic lymph nodes (LNs) stations, including skip metastasis. The aim of the study was to determine the effect of removed LNs on the adequacy of this new classification.The material was collected retrospectively based on the database of the Polish Lung Cancer Group, including information on 8016 patients with non-small cell lung cancer operated in 23 thoracic surgery centers in Poland. The material covered the period from January 2005 to September 2015. We divided patients into two groups: ≤6LNs and6LNs removed.In the whole group, an average of 13.4 nodes and 4.54 nodal stations were removed. 5-year survivals in the6LNs group vs ≤ 6LNs group were: 62.3% and 55.1% (N0), 44.5% and 35.9% (N1a), 34.1% and 31,7% (N1b), 37.3% and 26.3% (N2a1), 32.4% and 26.7% (N2a2), 29.4% and 29.2% (N2b1), and 22.0% and 23.0% (N2b2), respectively. Comparing these groups, we detected significant differences at N0 (p 0.001) and N2a1 (p = 0.022). In the ≤6LNs group, the survival curves for N2a1, N2a2, N2b1, and N2b2 overlapped (p 0.05). In the6LNs group, the survival curves were significantly different between grades, with survival for N2a1 better than N1b (p = 0.232).The proposed classification N descriptor is potentially better at differentiating patients into different stages. The accuracy of the classification depends on the number of lymph nodes removed. Therefore, the extent of lymphadenectomy has a significant impact on the staging of surgically-treated lung cancer. |
| Databáze: | OpenAIRE |
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